Diabetes:棕色脂肪可预防糖尿病和肥胖?

2014-07-25 王英 生物通

最近,加尔维斯顿德克萨斯大学医学分部(UTMB)的研究人员首次表明,具有更高水平棕色脂肪(或棕色脂肪组织)的人,他们的身体具有更好的血糖胰岛素敏感性和更好的燃烧脂肪代谢。 相关研究结果发表在最近的糖尿病顶级杂志 Diabetes 。结果表明,由于棕色脂肪能够更好地控制血糖,因此可能是对抗糖尿病的一种潜在医疗武器。 UTMB的老年医学部门的内科学教授Labros Sidossis指出:

最近,加尔维斯顿德克萨斯大学医学分部(UTMB)的研究人员首次表明,具有更高水平棕色脂肪(或棕色脂肪组织)的人,他们的身体具有更好的血糖胰岛素敏感性和更好的燃烧脂肪代谢。

相关研究结果发表在最近的糖尿病顶级杂志 Diabetes 。结果表明,由于棕色脂肪能够更好地控制血糖,因此可能是对抗糖尿病的一种潜在医疗武器。

同篇阅读:(亮点不同)Diabetes:把卧室弄凉点儿能使"好脂肪"大增

UTMB的老年医学部门的内科学教授Labros Sidossis指出:“我们发现,具有大量棕色脂肪组织储存的男性,暴露于轻度低温可提高其整个身体的能量消耗,增加循环中的葡萄糖去除,并改善胰岛素敏感性。这些结果支持了一种观点,即棕色脂肪组织可以作为一种抗肥胖和抗糖尿病的组织。”

在人体中有两种类型的脂肪组织:广受非议的白色脂肪组织和不太熟悉的棕色脂肪组织。白色脂肪过度的一个不良健康影响是胰岛素敏感度降低,这是糖尿病的一个主要促成因素。另一方面,棕色脂肪具有几个健康的特质,包括预防肥胖和糖尿病。

在研究中,Sidossis和同事们对具有或高或低棕色脂肪组织水平的其他类似健康男性进行分析,比较了他们的静息能量消耗、葡萄糖利用和胰岛素敏感性。这些男性被安置在正常温度条件下或暴露于轻度低温条件下,五到八个小时。

在暴露低温或常温条件的过程中,研究小组对各种身体样本进行了综合分析。他们收集了血液和呼吸样本,来观察血糖和胰岛素浓度、激素变化、全身氧消耗和二氧化碳生产率。他们还抽出棕色和白色脂肪组织样本,以分析细胞能量生产和基因表达的差异。

Sidossis称:“在这项研究中我们表明,当通过轻度的低温激活时,棕色脂肪组织能增加能量消耗和燃烧卡路里。这对于超重和肥胖者来说是个好消息。更大的临床意义在于,我们发现,棕色脂肪可以帮助身体更有效地调节血糖。这对于胰岛素抵抗和糖尿病患者来说是个好消息,表明棕色脂肪可能是一种重要的抗糖尿病组织。”

原始出处:


Chondronikola M1, Volpi E2, Børsheim E3, Porter C3, Annamalai P4, Enerbäck S5, Lidell ME5, Saraf MK3, Labbe SM6, Hurren NM3, Yfanti C7, Chao T8, Andersen CR3, Cesani F9, Hawkins H10, Sidossis LS11.Brown Adipose Tissue Improves Whole Body Glucose Homeostasis and Insulin Sensitivity in Humans.Diabetes. 2014 Jul 23. pii: DB_140746. [Epub ahead of print]


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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

    0

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    2014-09-21 智智灵药
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    2014-07-28 117.136.35.7

    新亮点!

    0

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