中国学者再发关于韩春雨基因技术论文:未发现有效

2016-11-13 记者王珏玢 黄堃 新华社

中国南通大学等机构研究人员在11日出版的新一期英国《自然》杂志子刊《细胞研究》上发表论文,报告了他们将NgAgo基因技术用于斑马鱼的研究结果。今年5月河北科技大学韩春雨团队在《自然》杂志子刊《自然·生物技术》上首次发表关于NgAgo基因技术的论文,并引发轰动和争议。这是自那之后,中国研究人员发表的有关NgAgo基因技术的第二篇学术论文。此次的论文由南通大学和复旦大学研究人员合作完成。论文通讯作者、

中国南通大学等机构研究人员在11日出版的新一期英国《自然》杂志子刊《细胞研究》上发表论文,报告了他们将NgAgo基因技术用于斑马鱼的研究结果。

今年5月河北科技大学韩春雨团队在《自然》杂志子刊《自然·生物技术》上首次发表关于NgAgo基因技术的论文,并引发轰动和争议。这是自那之后,中国研究人员发表的有关NgAgo基因技术的第二篇学术论文。

此次的论文由南通大学和复旦大学研究人员合作完成。论文通讯作者、南通大学神经再生重点实验室副教授刘东对新华社记者介绍说,在这项研究中,研究人员将NgAgo基因技术用于改变斑马鱼的基因fabp11a。结果发现,这可以“敲低”该基因,并因此导致斑马鱼眼部发育缺陷。但是在学术上,“敲低”基因并不等于“编辑”基因,这项研究并没有发现NgAgo技术有基因编辑功能。

研究人员表示,由于研究对象不同,此次研究“不能对此前韩春雨的结论证实或证伪”。

此前韩春雨团队在其论文中报告说,他们发明了新的基因编辑技术NgAgo-gDNA。这篇论文一经发表便引起全球生物学界巨大关注,因为基因编辑是当前的热门领域,主流技术是美国科研人员的CRISPR-Cas9技术。而根据论文,NgAgo-gDNA技术与CRISPR-Cas9技术相比在一些方面具有优势。

但随后中国以及国外都有学者公开表示无法重复论文中描述的实验,这项研究成果遭到多方质疑。《自然·生物技术》目前仍在继续调查这一事件,尚未做出进一步的决定。

刘东对记者说,他们此次的研究在斑马鱼模型上没有发现NgAgo技术有基因编辑功能,“但并不能支持或者反驳此前韩春雨的实验结果。”

记者就此联系了韩春雨,但未获正式回复。

北京大学生物学家饶毅教授就此表示,要对NgAgo技术作出评价,还需要等待更多的研究结果。

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    2016-11-13 艳阳天2016

    等待老师的重复实验结果

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2041903, encodeId=ecb5204190316, content=<a href='/topic/show?id=572941e5092' target=_blank style='color:#2F92EE;'>#基因技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41750, encryptionId=572941e5092, topicName=基因技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jun 13 04:19:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1550934, encodeId=108115509346a, content=<a href='/topic/show?id=662810003e92' target=_blank style='color:#2F92EE;'>#韩春雨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100037, encryptionId=662810003e92, topicName=韩春雨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Nov 14 15:19:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155500, encodeId=62e415550039, content=等待老师的重复实验结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Sun Nov 13 16:56:02 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155457, encodeId=4ca515545e62, content=学术争鸣值得推崇, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dd71722896, createdName=studylzc, createdTime=Sun Nov 13 12:26:21 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155410, encodeId=bd6f155410fd, content=哎!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Sun Nov 13 09:29:03 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155394, encodeId=7b7c1553949d, content=争论,争议。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Nov 13 08:17:42 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155388, encodeId=e768155388ab, content=学术造假,遗害无穷,但愿不是造假!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Sun Nov 13 08:06:42 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155355, encodeId=117d155355bd, content=不管怎样,希望都是对科学负责的态度。, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5WdRCZb0Hs1YiaOB88m23a0oYulDm9Z0Es2N8rk8dmG1tkgXOibgBGBTMpwlof4aic6HdrIeR2zF09okwsgRbedK0/0, createdBy=72f41927023, createdName=Johnson_zhangdr, createdTime=Sun Nov 13 01:51:53 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155345, encodeId=0cc0155345a9, content=中国文人相轻, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a3e1625700, createdName=18719ba4d5m, createdTime=Sun Nov 13 00:40:50 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-13 studylzc

    学术争鸣值得推崇

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2041903, encodeId=ecb5204190316, content=<a href='/topic/show?id=572941e5092' target=_blank style='color:#2F92EE;'>#基因技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41750, encryptionId=572941e5092, topicName=基因技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jun 13 04:19:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1550934, encodeId=108115509346a, content=<a href='/topic/show?id=662810003e92' target=_blank style='color:#2F92EE;'>#韩春雨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100037, encryptionId=662810003e92, topicName=韩春雨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Nov 14 15:19:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155500, encodeId=62e415550039, content=等待老师的重复实验结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Sun Nov 13 16:56:02 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155457, encodeId=4ca515545e62, content=学术争鸣值得推崇, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dd71722896, createdName=studylzc, createdTime=Sun Nov 13 12:26:21 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155410, encodeId=bd6f155410fd, content=哎!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Sun Nov 13 09:29:03 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155394, encodeId=7b7c1553949d, content=争论,争议。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Nov 13 08:17:42 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155388, encodeId=e768155388ab, content=学术造假,遗害无穷,但愿不是造假!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Sun Nov 13 08:06:42 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155355, encodeId=117d155355bd, content=不管怎样,希望都是对科学负责的态度。, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5WdRCZb0Hs1YiaOB88m23a0oYulDm9Z0Es2N8rk8dmG1tkgXOibgBGBTMpwlof4aic6HdrIeR2zF09okwsgRbedK0/0, createdBy=72f41927023, createdName=Johnson_zhangdr, createdTime=Sun Nov 13 01:51:53 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155345, encodeId=0cc0155345a9, content=中国文人相轻, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9a3e1625700, createdName=18719ba4d5m, createdTime=Sun Nov 13 00:40:50 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-13 䖝二

    哎!

    0

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    2016-11-13 刘煜

    争论,争议。

    0

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    2016-11-13 laoli

    学术造假,遗害无穷,但愿不是造假!

    0

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    2016-11-13 Johnson_zhangdr

    不管怎样,希望都是对科学负责的态度。

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    2016-11-13 18719ba4d5m

    中国文人相轻

    0

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