关于韩春雨论文事件,《自然·生物技术》全新回复

2016-10-25 知识分子 知识分子

导语:《自然·生物技术》已经收到了关于韩春雨文章的多个意见,并且已经考虑了或正在谨慎考虑这些意见过去几个月,韩春雨论文结果的可重复性争议引发公众的巨大关注。10月10日,12名(后增加1人变为13名)中国科学家通过媒体发表声明称无法重复或再现韩春雨今年5月2日发表在《自然·生物技术》(Nature Biotechnology)的论文实验结果。►2016年5月2日,《自然·生物技术》在线发表了河

导语:《自然·生物技术》已经收到了关于韩春雨文章的多个意见,并且已经考虑了或正在谨慎考虑这些意见

过去几个月,韩春雨论文结果的可重复性争议引发公众的巨大关注。

10月10日,12名(后增加1人变为13名)中国科学家通过媒体发表声明称无法重复或再现韩春雨今年5月2日发表在《自然·生物技术》(Nature Biotechnology)的论文实验结果。

►2016年5月2日,《自然·生物技术》在线发表了河北科技大学副教授韩春雨担任通讯作者的一篇论文,论文报道了一种新的基因编辑工具NgAgo可以在哺乳动物细胞中使用。



10月20日,《知识分子》获悉,包括这12名科学家在内的多位中国科学家已经向《自然·生物技术》期刊提交他们的实验结果及批评意见。随后,《知识分子》与《自然·生物技术》取得联系,询问他们是否已经接收到中国科学家的反馈意见。

10月22日,《自然·生物技术》的一位新闻发言人回答了我们的问题。

►Q1: 你们是否收到了中国科学家提交的关于韩春雨等人发表在《自然·生物技术》论文的批评意见?

A1:我们无法对收到的具体的反馈置评,但我们可以确认的是,我们已经收到了关于这一文章的多个意见,并且已经考虑了或正在谨慎考虑这些意见。 

我们提供一些关于《自然·生物技术》如何处理针对论文不同批评的说明,希望这会有所帮助: 

总的来说,对《自然·生物技术》的批评意见经过同行评议之后,可能会被刊登。 

如果来函(Correspondences)特别令人感兴趣,或是对原始研究论文重要的科学评论和澄清说明,或是关于其他已经发表、经过同行评议的材料,它们会与原文作者的回应一起刊登(如果原文作者选择提供回应的话)。

来函与原始论文的网址相互链接。 

有一些提交的批评意义如此重大,以至于让作者或编辑(在同行评议的帮助下)推断出论文的基本结论是无效的——这种情况下,论文会被撤稿。如果有必要突出和澄清原始论文的问题,来函可能会与撤稿声明一起刊登。 

►Q2: 《自然·生物技术》如何看待这些中国科学家的批评?《自然·生物技术》会为它们安排同行评议吗?如果会,《自然·生物技术》会披露结果吗? 

A2: 《自然·生物技术》对提交给杂志的一切批评和关注都认真对待,并谨慎考虑。如上所说,如果合适,我们将与发表的论文一起刊登读者来函。 

我们认真对待自己对已发表论文更新的责任,但没有两个调查是一样的,调查可能需要相当一段的时间。让调查按照应有的程序进行,不预先判断结果很重要,因为指控可能被证明是基于事实或没有根据的。 


附:《自然·生物技术》答复原文

Q1:Have you received the complaint of Gao et al. Nat. Biotechnol 34, 768-773 submitted by these Chinese scientists? 

A1:We cannot comment on specific feedback received but we can confirm that we have received numerous communications relating to this paper and have considered or are considering them carefully. 

We hope it will be useful to provide some information about how criticisms are handled for any Nature Biotechnology papers: 

In general, critical comments of Nature Biotechnology papers may, after peer review, be published. 

Correspondences are exceptionally interesting or important scientific comments and clarifications on original research papers or other published peer-reviewed material and they are published alongside a response from the original authors (if they choose to provide one).

Correspondences are linked bidirectionally with the original published paper. 

Some submitted criticisms are so significant that they lead the authors or editors (with the assistance of peer reviewers) to conclude that the fundamental conclusions of the paper are invalid. In these cases a paper would be retracted. 

Correspondences may be published alongside retractions if it is important to highlight and clarify issues in the original paper. 

Q2: What does Nature Biotechnology think of this complaint? Will Nature Biotechnology start a peer review of this complaint? If so, will Nature Biotechnology disclose the conclusion? 

A2: Nature Biotechnology takes all complaints and concerns raised with the journal seriously and considers them carefully. As described above, where appropriate, we will publish Correspondences alongside published papers. 

We take our responsibility to keep published literature up to date seriously, but no two investigations are the same and investigations can take a considerable length of time. It is important to allow them to run their course and not prejudge the results, as accusations may or may not be proven to have foundation.

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    2016-10-26 lyh994

    梅斯的推荐阅读,能不能推荐一些有科学价值的文章?

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1980909, encodeId=f19c19809093f, content=<a href='/topic/show?id=7fe66934067' target=_blank style='color:#2F92EE;'>#生物技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69340, encryptionId=7fe66934067, topicName=生物技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f54230, createdName=xlysu, createdTime=Sat Jan 21 16:42:00 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1550931, encodeId=411015509316d, content=<a href='/topic/show?id=662810003e92' target=_blank style='color:#2F92EE;'>#韩春雨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100037, encryptionId=662810003e92, topicName=韩春雨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Oct 27 14:42:00 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151328, encodeId=7a9315132811, content=梅斯的推荐阅读,能不能推荐一些有科学价值的文章?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Wed Oct 26 11:56:13 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151316, encodeId=9814151316a3, content=科技就是怀疑中发展进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Oct 26 10:36:16 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151310, encodeId=942e151310c0, content=盲目地追求科研!而不是真正地在临床的基础上发展科研!有意思吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7bc1971589, createdName=1e161090m91(暂无匿称), createdTime=Wed Oct 26 10:05:35 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151299, encodeId=6b1015129915, content=过去几个月,韩春雨论文结果的可重复性争议引发公众的巨大关注。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Wed Oct 26 09:20:52 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151297, encodeId=39dc15129e88, content=这意思是不是说不基于假设而去求证?, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35891952837, createdName=shuihanli, createdTime=Wed Oct 26 09:14:57 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151296, encodeId=92131512963c, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Wed Oct 26 09:14:12 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151295, encodeId=cae715129580, content=中国人!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/2DFF4BB86B82D856D772910A5C19E1F7/100, createdBy=10b21957253, createdName=leoin, createdTime=Wed Oct 26 09:12:57 CST 2016, time=2016-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151293, encodeId=23f51512931e, content=哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqpHmshvaicEGAghibgnta8Db8gQkyA8CxsZpQslsrWs1sO6WD9TVfETjHoItXgx1g9z4PDdnlaKt9A/132, createdBy=8c931967404, createdName=dd林, createdTime=Wed Oct 26 09:11:46 CST 2016, time=2016-10-26, status=1, ipAttribution=)]
    2016-10-26 明崖

    科技就是怀疑中发展进步

    0

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    2016-10-26 1e161090m91(暂无匿称)

    盲目地追求科研!而不是真正地在临床的基础上发展科研!有意思吗?

    0

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    2016-10-26 邓启付

    过去几个月,韩春雨论文结果的可重复性争议引发公众的巨大关注。

    0

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    2016-10-26 shuihanli

    这意思是不是说不基于假设而去求证?

    0

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    2016-10-26 Guoxj3234

    学习起来

    0

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    2016-10-26 leoin

    中国人!

    0

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    2016-10-26 dd林

    0

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浙大教授:韩春雨有责任澄清学术质疑

我是王立铭,浙江大学生命科学研究院教授、研究员、博士生导师,一名普通的生命科学研究者。在这里,我谨代表我自己,简单总结一下我们实验室和合作者测试检验这一基于NgAgo的全新基因编辑技术的过程。

我们是在五月初,也就是韩春雨教授的论文刚刚上线的时候就关注到这一新技术的。必须得说,作为一个生物学研究者,我个人看到这篇论文的心情是挺复杂的。一方面,任何一个熟悉分子生物学的读者都会立刻意识到这项技术的潜在价值。众所周知,基因编辑技术能够帮助科学家和医生们精确地修改生物特定基因序列的信息,不管是对于基础研究还是对于潜在的临床应用都意义重大。从文章的数据分析,基于NgAgo的基因编辑技术能够克服目前主流基因编辑技术的弱点(例如脱靶性和对编辑序列的选择性),不管是在基础研究中还是在潜在临床应用中都甚至可能将后者取而代之。这样重量级的学术突破出现在中国,这样价值连城的知识产权握在中国学术机构和中

韩春雨基因编辑技术恐遭弃用:数百个基因中重复失败

导语:因为大面积无法重复实验,作者和所在单位又不出面应对质疑声,河北科技大学副教授韩春雨领衔的NgAgo基因编辑技术的重复工作已经遇冷。自2016年5月2日在《自然-生物技术》在线发表论文,NgAgo已经问世5个月,韩春雨在论文中描述的NgAgo是一项和目前主流的“基因魔剪”CRISPR拥有同样效率的基因编辑技术,能高效地实现对特定DNA片段的敲除、加入。但在近日哥本哈根举办的“CRISPR

徐星:在韩春雨事件中我们更该关注什么?

河北科技大学的韩春雨副教授这几个月来成了媒体关注的焦点,这也不奇怪,因为他的NgAgo论文从发表到现在,整个过程充满了激发公众兴趣和讨论的要素:他发现的基因编辑技术有可能开辟生物学的一个新领域,这让热望“中国第一”的媒体有了大力渲染民族自豪感的机会;作为一个来自省属院校的不知名学者,在占用很少资源的情况下,却做出巨大的成果,再次凸显了中国科学界的一个现象:知名高校和普通高校,大型和小型研究

韩春雨候选“中青年科技创新领军人才”,到底怎么解决韩春雨“疑云”?

继收获河北省科协副主席、“美丽河北·最美教师”头衔之后,河北科技大学副教授韩春雨正成为国家“中青年科技创新领军人才”的候选人之一。此前,7月,河北科技大学推荐韩春雨为2016年度“***奖励计划”人选候选人。
 
9月30日,河北科技大学官网一则名为《关于我校2016年国家创新人才推进计划暨“万人计划”科技创新领军人才、科技创业领军人才推荐人选的公示》的通告显示,韩春雨等四位在校教师成为“中青年科技创新领军人才”推荐人选。通告还表示,9月22日学校发布了申报通知,“校内共有4人进行申报,学校科研院对申报材料进行了严格审核”,共有4人入选推荐,公示期为3日,但没有标明如有异议,可联系何人。
 
· 2016-10-11

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从韩春雨说起:科学的“有罪推定”

摘要:韩春雨的一句话——“我为什么要自证清白,自己有病吗?”引发了严重后果,不仅13位中国科学家实名发声,要求启动对韩春雨的学术调查,而且也反映了我们这些吃瓜群众、他们专业人员和领导者对于科学的误解。但是,这也是好事,此事能帮助和促进所有人以接近正确的打开方式理解科学和对待科学,由此提高整个民族的科学素养。【在科学领域就是要奉行“有罪推定”原则,当然这仅仅是针对科学研究结果,而非对待科学家,尤其是

韩春雨面对质疑声称:实验没问题 已重复两次

国内外大量实验室为何无法重复其实验?“细胞污染”是韩春雨向同行和媒体常说的一个原因。  “别人可能会有疑问,怎么这么多人手里的细胞都是有问题的?我也从各种渠道购买,或者也从别人手里要了实验材料,把原来整个实验捋一遍,做一遍,确实发现,他们说做不出来确实是有原因的,我现在基本上确认其他实验室不能重复出来实验的一个很重要的原因是细胞污染,但我还要通过更严谨的实验去把这些东西找出来。”韩春雨解释道。