Thyroid:甲状腺未分化癌患者低淋巴细胞与单核细胞比率与总体存活率差有关

2019-07-05 xing.T MedSci原创

由此可见,低LMR与ATC患者的生存率低有关。LMR可能是一种简单而稳定的预后生物标志物,可反映ATC患者的宿主免疫力。需要进一步研究以确认LMR在ATC患者预后中的作用。

已有研究报道反映肿瘤浸润性免疫细胞状态和宿主免疫的淋巴细胞与单核细胞比率(LMR)可作为各种癌症的预后标志。近日,甲状腺疾病领域权威杂志Thyroid上发表了一篇研究文章,该研究的目的是评估LMR作为预测甲状腺未分化癌(ATC)患者生存的预后标志的价值。

该研究回顾性地分析了35例可获得全血细胞计数数据的ATC患者,主要结果是ATC患者的总生存期(OS)。

基线的LMR与随访的全血细胞计数数据之间没有显著差异(p=0.53)。根据基线LMR将患者分为两组:低LMR组(<4; n=23,66%)和高LMR组(≥4; n=12,34%)。低LMR组颈淋巴结转移的比例明显高于高LMR组(p=0.021)。OS曲线基于LMR值显著不同,低LMR组和高LMR组的中位OS分别为3.0和9.5个月(p=0.004)。在多变量分析中,在调整性别、肿瘤大小和远处转移后,低LMR也是ATC患者全因死亡率的独立危险因素(风险比=2.55,[置信区间为1.08-6.00],p=0.032)。

由此可见,低LMR与ATC患者的生存率低有关。LMR可能是一种简单而稳定的预后生物标志物,可反映ATC患者的宿主免疫力。需要进一步研究以确认LMR在ATC患者预后中的作用。

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    2019-07-05 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0