Biomaterials :美国科学家“揪出”癌细胞转移的罪魁祸首

2017-10-26 佚名 Medicalxpress

癌症之所以可怕就在于癌细胞的不受控性,癌细胞不进可以迅速的进行复制繁殖,还可以从一个器官转移到另一个器官,一旦癌症发生了转移,治疗似乎就变得不太可能。在一份新的研究中,研究人员着眼于细胞的移动过程。

癌症之所以可怕就在于癌细胞的不受控性,癌细胞不进可以迅速的进行复制繁殖,还可以从一个器官转移到另一个器官,一旦癌症发生了转移,治疗似乎就变得不太可能。在一份新的研究中,研究人员着眼于细胞的移动过程。

在人体形成的过程中,细胞移动形成器官,治愈伤口,癌细胞的移动则完成了癌症的转移。圣路易斯华盛顿大学的机械工程师们发现细胞记得他们在第一个环境中移动的属性,继而,如果癌症发生,它们的机械记忆就会复苏。

圣路易斯华盛顿大学工程和应用科学学院机械工程和材料科学教授,通过运用力学生物学,花费了三年时间找到了这些问题的答案,如果细胞从一个环境转移到另一个环境,他们还会记得第一个,这就是它们的机械记忆。研究结果发表于《生物材料》杂志中。

研究人员在报道中指出:“细胞为什么善于适应环境,人类有很多内存,如果细胞一直保持原有的记忆,就不太可能适应新环境,如果将过去的记忆删除,就更加利于它们适应新的环境。”

为了证明这一假设,研究人员创建了一个设备,可以测量细胞的记忆在新环境中持续的时间。设备具有两面障碍,研究人员模拟了恶性肿瘤的环境,将细胞置于其中,几天后删除了障碍,细胞迅速侵入设备的另一边,这是一个软环境。此外,他们发现这些细胞可以在新环境中保持属性,时间为三天,移除障碍类似于细胞逃离原发肿瘤周围组织转移的起源,这一发现有助于找到阻止和预防癌细胞转移的方法。

原始出处:
Samila,Nasrohi,hiaChristopher,Walter,Andrew J.Lozade,et al.Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory.Biomaterials.Volume 146, November 2017, Pages 146-155.https://doi.org/10.1016/j.biomaterials.2017.09.012

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    2018-08-05 sunylz
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    2017-10-28 yxch36
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    2017-10-28 zz72
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    2017-10-27 半夏微凉

    阅读了谢谢分享

    0

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    2017-10-26 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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