Br J Dermatol:通过右手臂痣的数目可有效预测患黑色素瘤风险

2015-10-20 MedSci 译 MedSci原创

英国伦敦国王学院Simon Ribero领导的研究人员最近完成的一项研究表明,通过人们右手臂胎记和痣的数目可预测他们患黑色素瘤的风险。这项研究发表在Dermatology。 在美国,黑色素瘤在所有皮肤癌病例所占比例不到2%,但所导致的患者死亡率极高。今年,美国新发73000多名黑色素瘤患者,预计近1万名患者将死于黑色素瘤。 胎记或痣是导致民众患黑色素瘤的高危风险因素,若一个人的胎记或痣越多,则其患

英国伦敦国王学院Simon Ribero领导的研究人员最近完成的一项研究表明,通过人们右手臂胎记和痣的数目可预测他们患黑色素瘤的风险。这项研究发表在British Journal of Dermatology。 


在美国,黑色素瘤在所有皮肤癌病例所占比例不到2%,但所导致的患者死亡率极高。今年,美国新发73000多名黑色素瘤患者,预计近1万名患者将死于黑色素瘤。 

胎记或痣是导致民众患黑色素瘤的高危风险因素,若一个人的胎记或痣越多,则其患黑色素瘤的风险越大。

根据Ribero和他的同事们得出的结论,每个痣的存在表明民众患黑色素瘤的风险增加2-4%。但研究人员指出,依靠计数民众全身胎记或痣的数目估计其患黑色素瘤的风险无异于浪费时间和精力。因此,研究人员开始探究是否可以依靠身体某个部位的胎记总数估计个体全身胎记总数,因此同样可评估民众患患黑色素瘤的风险。 

1995年1月到2003年12月,研究人员对3594名白人双胞胎女性进行研究。经过培训的护士对参与者17个身体区域的痣的数目进行了统计。然后研究人员在另一项小规模研究中对400名男性和女性进行了同样的痣的数目统计。

研究人员发现,人们的右臂可有效预测个体身体的痣总数。若女性右臂的痣超过7个,则全身痣的总数超过50个的可能性超过90%;若女性右臂的痣超过11个,则她们全身的痣至少100个,表明她们患黑色素瘤的风险是常人的5倍。

Ribero博士认为,通过计数人们右手臂的痣的数目预计全身痣的数目,这种方法可有效估计人们患黑色素瘤的风险,并可及时有效做出防范措施和风险筛查。 

Ribero S, Zugna D, Osella-Abate S, Glass D, Nathan P, Spector T, Bataille V.Prediction of high naevus count in a healthy uk population to estimate melanoma risk.Br J Dermatol. 2015 Oct 19. 


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    2015-12-27 忠诚向上

    很值得好学习

    0

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    2016-03-20 sunylz
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    2015-10-22 yese
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