NEJM：发现与睾丸癌有关的自身免疫性疾病

2021-07-09 Viho MedSci原创

科学家们利用先进技术，发现了一种似乎会影响男性睾丸癌患者的自身免疫疾病。这种疾病被称为 "睾丸癌相关的副肿瘤性脑炎"，会导致男性出现严重的神经系统症状。

科学家们利用先进技术，发现了一种似乎会影响男性睾丸癌患者的自身免疫疾病。这种疾病被称为 "睾丸癌相关的副肿瘤性脑炎"，会导致男性出现严重的神经系统症状。他们逐渐失去对四肢、眼睛运动的控制，在某些情况下还会失去语言能力。这种疾病始于睾丸肿瘤，它似乎导致免疫系统攻击大脑。受影响的男性经常发现自己被误诊或未被诊断，适当的治疗被推迟。发表于New England Journal of Medicine的一项研究中，科学家们通过使用 "可编程噬菌体显示 "技术的一个变体，它是一种改进的人类可编程显示系统，为筛选新抗原而设计的，可以确定了该疾病的一个高度特异和独特的生物标志物。研究人员对这种技术的改进版本同时筛选了所有人类蛋白质中的70多万个自身抗体目标。利用这一强大的工具，加州大学旧金山分校的研究人员评估了一名37岁男子的脑脊液，该男子有睾丸癌病史，并有衰弱的神经系统症状，包括眩晕、肢体不协调和说话不清。增强的噬菌体技术确定了针对Kelch样蛋白11（KLHL11）的自身抗体，该蛋白存在于睾丸和部分大脑中。副肿瘤性菱形脑炎患者血清抗KLHL 11抗体的发现及正交验证。这些结果其他病人样本

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2022-01-26 ms4000002110537530

有意思

51 0
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2021-07-30 小小医者

#自身免疫性疾病#与#睾丸癌#

125 0
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2021-07-30 ms7919221313595046

nice

71 0
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2021-07-13 走，走走

有意思

66 0
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2021-07-11 zhangph

#睾丸#

47 0
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2021-07-11 124988c7m100暂无昵称

#免疫性疾病#

36 0
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2021-07-10 1209e435m98(暂无昵称)

学习了，谢谢分享

70 0
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2021-07-10 旺医

顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

41 0
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2021-07-10 仁术2021

不错学习了

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