Cell Rep:草本植物也会运输感染性的朊病毒

2015-05-20 佚名 生物谷

近日,刊登在国际杂志Cell Reports上的一篇研究论文中,来自德克萨斯大学健康科学中心的研究人员通过研究发现,草本植物也可以结合、吸收并且运输感染性的朊病毒;朊病毒是一种引发传染性海绵状脑病的以蛋白质为基础的传染原,其引发的传染性海绵状脑病包括牛海绵状脑病、绵羊疯痒病、人类的克雅氏病及鹿的慢性消耗性疾病(CWD),所有的致死性脑部疾病都会在机体潜伏数年。 研究者Claudio Soto

近日,刊登在国际杂志Cell Reports上的一篇研究论文中,来自德克萨斯大学健康科学中心的研究人员通过研究发现,草本植物也可以结合、吸收并且运输感染性的朊病毒;朊病毒是一种引发传染性海绵状脑病的以蛋白质为基础的传染原,其引发的传染性海绵状脑病包括牛海绵状脑病、绵羊疯痒病、人类的克雅氏病及鹿的慢性消耗性疾病(CWD),所有的致死性脑部疾病都会在机体潜伏数年。

研究者Claudio Soto表示,目前并没有证据显示朊病毒可以从野生动物和植物向人类机体传播,但我们需要大量的研究来揭示朊病毒的传播机制,而且公众也应该对其有所认知; 20世纪60年代研究者在美国科罗拉多州首次诊断出CWD,该疾病当时已经在美国22个州引发的扩散。

文章中研究者分析了用感染性脑部药品孵育的小麦根部及叶片的感染性朊病毒的保留能力以及感染性,结果发现甚至在高稀释度下朊病毒也会吸附结合到小麦的根部也叶部,当小麦被仓鼠食用后,动物就会感染朊病毒;随后研究人员表示,当植物暴露于被朊病毒感染的仓鼠和麋鹿的尿液中时,我们也会在植物中检测到感染性朊病毒的存在。

随后研究人员发现,植物可以通过被污染的土壤来摄取朊病毒,并且将其运输至植物的不同部位,而植物的不同部位就会扮演感染性朊病毒载体的角色,因此植物在环境中朊病毒污染及疾病传播上扮演着重要的角色。为了尽量降低动物暴露于CWD的风险,CDC的研究人员建议人们应该避免食用那些看起来患病或CWD阳性的麋鹿,而在朊病毒感染区域的捕猎者最好尽量减少捕猎的频率,下一步研究人员希望将研究推向受污染的环境中来进一步揭示朊病毒的感染和传播途径及机制。

原始出处:

Sandra Pritzkow, Rodrigo Morales, Fabio Moda3, Uffaf Khan, Glenn C. Telling, Edward Hoover, Claudio Soto.Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions.Cell Reports, May 14, 2015.DOI: http://dx.doi.org/10.1016/j.celrep.2015.04.036

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    2016-03-24 维他命
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    2015-05-20 sumer

    这个世界太危险了!!

    0