J Rheumatol:类风湿性关节炎相关性炎性眼病的临床相关性、预后和预测因子

2018-03-15 xiangting MedSci原创

这项大型单中心研究强调了RA中IOD的不同表现和预后。虽然眼部并发症与显著的发病率相关。

炎性眼病(IOD)是类风湿性关节炎罕见但严重的关节外表现(ExRA),其死亡率高。这项研究的目的是探讨近年来类风湿性关节炎(RA)中IOD的临床特征及其对疾病严重程度和预后的影响。

对1996年至2013年间评估的伴IOD的RA患者回顾性队列进行汇总,并与不伴IOD的RA患者进行比较,根据年龄、性别和病程进行匹配。

共确定了92例伴IOD患者(女性69%,平均年龄62岁):巩膜炎33例,表层巩膜炎23例,外周溃疡性角膜炎(PUK)21例,葡萄膜炎14例,眼眶炎症1例。大多数巩膜炎、表层巩膜炎和PUK患者比葡萄膜炎的血清阳性率多(> 80%vs 62%,p = 0.048)。与表层巩膜炎和葡萄膜炎相比,PUK和巩膜炎症状更多,并且通常需要全身治疗。巩膜炎的缓解时间要长于表层巩膜炎(p = 0.01)。PUK,巩膜炎和葡萄膜炎有严重的眼后遗症。IOD患者的严重ExRA患病率(18%vs 4%,p = 0.004)和干眼症(42%vs 26%,p = 0.024)高于对照。新的ExRA在5年随访中的发病率也较高(29%vs 11%,p = 0.022)。在伴和不伴IOD的RA患者中,10年生存率相似(66%vs 64%,p = 0.56),IOD亚型之间没有差异。

这项大型单中心研究强调了RA中IOD的不同表现和预后。虽然眼部并发症与显著的发病率相关,但可以肯定的是,IOD患者的生存率与无眼部疾病的患者相似。

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    2018-03-17 lmm397
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    2018-03-17 pps20023

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