AJG:抑郁症状缓解与工作效率提高有显著联系

2013-07-18 wangrui cmt

7月《美国精神病学杂志》(The American Journal of Psychiatry)网络版收载的一篇研究论文显示,在初始治疗中临床症状显著缓解的患者较治疗抵抗者更易体验到显著的工作效率提高;相对的,在第二阶段治疗中症状得到缓解的患者仍会存在工作障碍;存在一定程度的治疗抵抗的患者更倾向于出现工作效率的持续损害,这暗示此类患者需要一种额外的、新型的治疗方法。 研究者试图确定门诊抑

7月《美国精神病学杂志》(The American Journal of Psychiatry)网络版收载的一篇研究论文显示,在初始治疗中临床症状显著缓解的患者较治疗抵抗者更易体验到显著的工作效率提高;相对的,在第二阶段治疗中症状得到缓解的患者仍会存在工作障碍;存在一定程度的治疗抵抗的患者更倾向于出现工作效率的持续损害,这暗示此类患者需要一种额外的、新型的治疗方法。

研究者试图确定门诊抑郁患者的与工作效率相关的基线临床特征和社会人口学特征,并评估治疗对其工作效率的影响。研究共招募了1928名年龄在18-75岁的抑郁患者,参与者需事先完成工作效率与活动障碍量表,每日服用西酞普兰20-40mg,进行序贯治疗缓解抑郁研究。经初始足量抗抑郁药试验(阶段1)后未缓解的患者,可更换为舍曲林、安非他酮缓释剂、文拉法辛缓释剂、安非他酮或丁螺环酮缓释剂加增强剂(阶段2)。研究评估了参与者与基线工作效率相关的临床和社会人口学特征、治疗转归及工作效率随时间的改变。

参与者的教育程度、基线抑郁程度、忧郁症的、非典型的及复发的抑郁症亚型均与工作效率低下独立相关。第一治疗阶段中,在一部分工作效率通过抑郁症状改善儿提高,尽管,这些发现并没有被第二阶段的转归验证;工作障碍的治愈与缓解间无显著联系;当纳入多重归因对丢失数据进行处理后,研究结果在很大程度上得到了证实,在此附加评估中发现严重的工作效率损害与较高的焦虑抑郁水平相关。


Increase in Work Productivity of Depressed Individuals With Improvement in Depressive Symptom Severity  

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1650948, encodeId=47131650948e6, content=<a href='/topic/show?id=82d74e8850d' target=_blank style='color:#2F92EE;'>#工作效率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47885, encryptionId=82d74e8850d, topicName=工作效率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26da24104226, createdName=chenshujs, createdTime=Mon May 12 05:49:00 CST 2014, time=2014-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057230, encodeId=64f1205e23060, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Fri Apr 04 18:49:00 CST 2014, time=2014-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434854, encodeId=27511434854cf, content=<a href='/topic/show?id=952a54980e5' target=_blank style='color:#2F92EE;'>#抑郁症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54980, encryptionId=952a54980e5, topicName=抑郁症状)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jul 20 06:49:00 CST 2013, time=2013-07-20, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1650948, encodeId=47131650948e6, content=<a href='/topic/show?id=82d74e8850d' target=_blank style='color:#2F92EE;'>#工作效率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47885, encryptionId=82d74e8850d, topicName=工作效率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26da24104226, createdName=chenshujs, createdTime=Mon May 12 05:49:00 CST 2014, time=2014-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057230, encodeId=64f1205e23060, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Fri Apr 04 18:49:00 CST 2014, time=2014-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434854, encodeId=27511434854cf, content=<a href='/topic/show?id=952a54980e5' target=_blank style='color:#2F92EE;'>#抑郁症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54980, encryptionId=952a54980e5, topicName=抑郁症状)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jul 20 06:49:00 CST 2013, time=2013-07-20, status=1, ipAttribution=)]
    2014-04-04 minzju5052
  3. [GetPortalCommentsPageByObjectIdResponse(id=1650948, encodeId=47131650948e6, content=<a href='/topic/show?id=82d74e8850d' target=_blank style='color:#2F92EE;'>#工作效率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47885, encryptionId=82d74e8850d, topicName=工作效率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26da24104226, createdName=chenshujs, createdTime=Mon May 12 05:49:00 CST 2014, time=2014-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057230, encodeId=64f1205e23060, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Fri Apr 04 18:49:00 CST 2014, time=2014-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434854, encodeId=27511434854cf, content=<a href='/topic/show?id=952a54980e5' target=_blank style='color:#2F92EE;'>#抑郁症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54980, encryptionId=952a54980e5, topicName=抑郁症状)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Jul 20 06:49:00 CST 2013, time=2013-07-20, status=1, ipAttribution=)]