AAAAI 2016:慢性鼻窦炎鼻息肉患者常出现阿司匹林加重性呼吸系统疾病

2016-04-19 MedSci MedSci原创

据美国过敏、哮喘和免疫学会2016年会上展示的一项新的研究显示, 16%的慢性鼻窦炎鼻息肉患者可出现阿司匹林加重性呼吸系统疾病,且阿司匹林加重性呼吸系统疾病与更重疾病的发生有关。

据美国过敏、哮喘和免疫学会2016年会上展示的一项新的研究显示, 16%的慢性鼻窦炎鼻息肉患者可出现阿司匹林加重性呼吸系统疾病,且阿司匹林加重性呼吸系统疾病与更重疾病的发生有关。

“阿司匹林加重性呼吸系统疾病(AERD)包括慢性鼻窦炎伴鼻息肉(CRSwNP),哮喘和不耐受COX-1酶抑制剂(如阿司匹林)三联征,”来自西北大学费因伯格医学院的Whitney W. Stevens博士说道,“AERD的患病率仍不清楚,很少有研究对比了AERD患者与不伴有CRS的CRSwNP或哮喘患者的临床特征。”

该研究中,通过搜索一家三级医疗中心的电子医疗记录Stevens及其同事确定了459名CRSwNP患者,同时存在CRSwNP和哮喘的412名患者以及173名AERD患者。使用相同的医疗记录,研究人员建立了一个对照组,包括300名哮喘患者,以评估其肺功能,鼻窦手术和口服糖皮质激素的使用。

16%的仅存在CRSwNP的患者出现了AERD。与仅存在CRSwNP的患者相比, AERD患者接受鼻窦手术的次数为其二倍,且年龄平均年轻3岁。

此外,研究人员发现,83% 的AERD患者出现特应性反应, 85%的哮喘患者出现特应性反应,但是仅有66%的CRSwNP患者出现特应性反应。与哮喘患者相比,AERD患者的FEV1较低(80% vs 86%)。

13%的AERD患者存在皮质类固醇激素依赖性疾病,而仅有4%同时存在鼻息肉和哮喘的患者存在此疾病,而对于哮喘患者仅有 1%的患者存在此疾病。

最后,Stevens 说道,“这是对比了手术和非手术治疗的AERD患者与CRSwNP患者和哮喘患者的最大型研究中的一个研究。”

原始出处:

Will Offit. Aspirin-exacerbated respiratory disease common in chronic rhinosinusitis with nasal polyps. Healio, April 2016.

Stevens WW, et al. Abstract 210. Presented at: American Academy of Allergy, Asthma & Immunology Annual Meeting; March 4-7, 2016; Los Angeles.

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    2016-09-11 doctorJiangchao

    继续学习

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    2016-09-11 doctorJiangchao

    继续关注

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    2016-08-26 ylzr123

    深度好文,赞一个!!!

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    2016-07-28 刘煜

    学习新知识,增长新见识。

    0

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    2017-03-09 ay2000fy
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