CLIN CANCER RES：T细胞归巢疗法可以减少调节性T细胞并维持实体瘤中效应T细胞功能

2018-06-29 MedSci MedSci原创

输入的自体肿瘤浸润淋巴细胞（TIL）和CAR T细胞通常会包绕恶性区域或浸润小的肿瘤结节，但是无法进入大的实体肿瘤，因此会显着影响其抗肿瘤效果。需要新的治疗策略来克服这一障碍。CLIN CANCER RES近期发表了一篇文章研究这一问题。

输入的自体肿瘤浸润淋巴细胞（TIL）和CAR T细胞通常会包绕恶性区域或浸润小的肿瘤结节，但是无法进入大的实体肿瘤，因此会显着影响其抗肿瘤效果。需要新的治疗策略来克服这一障碍。CLIN CANCER RES近期发表了一篇文章研究这一问题。

作者在鼠肺癌模型，鼠乳腺癌肺转移模型和两个人肿瘤移植模型中研究实体瘤中IL12联合阿霉素对T细胞浸润和功能的影响。研究结果表明，这一简单的处理措施会增加肿瘤中浸润CD8+T细胞的数量，分布及浸润深度，包括TIL和CAR T细胞。这一联合处理措施可以抑制肿瘤进展并显着延长生存时间。机制研究发现其发挥作用的原因有多个。首先，联合处理使得CD8+T细胞免疫刺激受体与免疫抑制受体的比值很高，降低免疫抑制性调节性T细胞募集，增强肿瘤中T-bet+效应T细胞。其次，阿霉素诱导细胞因子CXCL9和CXCL10，会诱导NKG2D+CD8+T细胞向肿瘤迁移，而肿瘤中IL-12诱导的IFNγ升高会进一步增强这一效果，促进NKG2D+CD8+T细胞浸润。

文章最后认为，与IL12加阿霉素联合处理有关的T细胞浸润增强在鼠和人肿瘤移植模型中均取得了良好的治疗效果。这一措施可能会使得T细胞治疗的范围扩大到实体肿瘤。

原始出处：

Jiemiao Hu,Chuang Sun,et al.T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors.CLIN CANCER RES June 2018 doi:10.1158/1078-0432.CCR-17-1365

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2018-07-15 1e145228m78(暂无匿称)

学习了.谢谢作者分享!

84 0
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2018-07-02 童小孩

学习

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2018-07-02 1e145228m78(暂无匿称)

学习了.谢谢作者分享!

66 0
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2018-07-02 大爰

学习了谢谢分享!!

93 0
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2018-07-01 般若傻瓜

#细胞功能#

33 0
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2018-06-30 kafei

学习学习谢谢

75 0
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2018-06-29 1e1b8538m79(暂无匿称)

不错的文章值得拥有哦

22 0
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2018-06-29 orangesking

看看

23 0
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2018-06-29 天地飞扬

了解一下.谢谢分享!

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