Immunity：清华大学免疫所林欣课题组揭示肠道真菌调控髓系抑制性细胞参与结肠肿瘤发病的新机制

2018-09-21 佚名清华免疫

该研究证实了CARD9介导的抗真菌免疫应答在维持肠道稳态和诱导肠道肿瘤中的重要作用，阐述了肠道共生真菌在结肠肿瘤发病中机制，对于临床结肠肿瘤的诊治具有重要的指导意义。

2018年9月18日，清华大学医学院免疫学研究所林欣教授课题组和南京大学医学院王婷婷教授课题组在Cell子刊《Immunity》杂志在线发表题为《 The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells 》的研究论文。

结直肠癌（Colorectal cancer， CRC）是大肠上皮黏膜在环境及遗传等多致病因素作用下发生的恶性转化。高度完整和调节完善的肠道免疫系统是维持肠道上皮黏膜功能正常及抑制肠道肿瘤发生发展的有效武器。而肠组织特异性免疫形成的关键因素是肠道免疫识别分子对肠道不同菌群及其代谢产物的反应。因此，探讨肠道微生物及其介导的免疫应答对于开拓免疫治疗在结直肠癌中的应用至关重要。

肠道菌群是指在人体肠道中存在的种类繁多、数目惊人的微生物群体。普遍认为，肠道菌群参与炎症性肠病以及肥胖等代谢性疾病的发生，但关于肠道共生真菌介导的免疫应答是否影响结肠肿瘤的发生尚无报道。胱天蛋白酶募集域蛋白（CARD9）是一种表达于髓系细胞的接头蛋白，是C型凝集素样受体的下游分子。CARD9不仅能够识别细菌、真菌、病毒和内源性危险信号，还能形成CARD9-BCL10-MALT1（CBM）信号复合体，是NF-κB和MAPK等炎症信号通路的上游分子，可促进巨噬细胞等产生和释放炎症因子，在真菌感染性疾病中发挥重要的作用。

2013年，王婷婷入选“南京大学中青年优秀教师境外研修项目”前往当时在MD Anderson Cancer Center 的林欣教授实验室做博士后期间发现Card9-/-鼠比野生鼠易患炎症相关结肠肿瘤。值得关注的是Card9-/-鼠肠道中真菌的数量，尤其是条件致病真菌热带念珠菌（C. tropicalis）的数量显着高于正常鼠；Card9-/-鼠在肠道肿瘤诱导过程中予 C. tropicalis灌胃可显着加重炎性病变及肿瘤负荷，而给予氟康唑抗真菌治疗后，Card9-/鼠结肠肿瘤负荷显着减轻，提示我们在Card9-/-鼠中增多的肠道真菌促进了结肠肿瘤的进程。

2016年，王婷婷教授回国后继续同林欣实验室合作，进一步研究肠道真菌调控结肠肿瘤进展的分子机制，研究发现上述现象与髓系抑制性细胞（MDSCs）密切相关。MDSCs是一类具有免疫抑制性的未成熟骨髓细胞，它们可通过抑制T细胞的活性促进肿瘤的生长。MDSCs增多导致的免疫抑制已成为肿瘤患者预后差、治疗效果不理想的重要原因。该研究发现在Card9-/-结肠肿瘤鼠中MDSCs的比例，尤其是粒样的髓系抑制细胞（G-MDSCs）显着增多，且MDSCs对CD4+ T细胞和CD8+ T细胞的抑制能力显着增强。进一步的实验首次证实肠道真菌的刺激可以促进髓系细胞向MDSCs的分化，并激活MDSCs的免疫抑制活性。

综上所述，本研究证实：在正常状态下，肠道共生真菌C.tropicalis可易位至肠道固有层，通过CARD9分子被宿主的天然免疫细胞----巨噬细胞识别清除。而在CARD9分子缺失时，增多的C.tropicalis 可促进髓系细胞向MDSCs细胞分化，并激活MDSCs的免疫抑制活性，从而促进结肠肿瘤的发生发展（图1）。该研究证实了CARD9介导的抗真菌免疫应答在维持肠道稳态和诱导肠道肿瘤中的重要作用，阐述了肠道共生真菌在结肠肿瘤发病中机制，对于临床结肠肿瘤的诊治具有重要的指导意义。

该课题由南京大学与清华大学合作完成，南京大学王婷婷教授与清华大学林欣教授为本文共同通讯作者。该研究得到了国家自然科学基金委、江苏省自然科学基金和中央高校基本科研业务费的支持，课题前期实验由美国NIH基金支持。

图1：肠道真菌调控MDSCs参与结肠肿瘤发病的机制示意图

原始出处：Tingting Wang, Chaogang Fan, Anran Yao, et al. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. SEPTEMBER 18, 2018

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2019-02-10 12498d2fm51(暂无昵称)

#Immunity#

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2018-10-22 chenlianhui

#结肠肿瘤#

32 0
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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346054, encodeId=d409346054e3, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/10/b92c6fe1729451c8d4b3a5c04e1396c6.jpg, createdBy=dfe32402282, createdName=西西er, createdTime=Fri Sep 21 22:30:13 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345973, encodeId=4d503459e33f, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2019-02-13 闆锋旦

#肠道真菌#

42 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8e425737, createdName=tw007007, createdTime=Wed Sep 26 16:29:07 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353751, encodeId=f53c1353e512f, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500135, encodeId=51fd150013531, content=<a href='/topic/show?id=9e6866216d7' target=_blank style='color:#2F92EE;'>#清华#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346054, encodeId=d409346054e3, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/10/b92c6fe1729451c8d4b3a5c04e1396c6.jpg, createdBy=dfe32402282, createdName=西西er, createdTime=Fri Sep 21 22:30:13 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345973, encodeId=4d503459e33f, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-26 tw007007

谢谢分享，学习了，感谢

59 0
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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346054, encodeId=d409346054e3, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/10/b92c6fe1729451c8d4b3a5c04e1396c6.jpg, createdBy=dfe32402282, createdName=西西er, createdTime=Fri Sep 21 22:30:13 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345973, encodeId=4d503459e33f, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-22 zhaojie88

#真菌#

21 0
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8e425737, createdName=tw007007, createdTime=Wed Sep 26 16:29:07 CST 2018, time=2018-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353751, encodeId=f53c1353e512f, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500135, encodeId=51fd150013531, content=<a href='/topic/show?id=9e6866216d7' target=_blank style='color:#2F92EE;'>#清华#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346054, encodeId=d409346054e3, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/10/b92c6fe1729451c8d4b3a5c04e1396c6.jpg, createdBy=dfe32402282, createdName=西西er, createdTime=Fri Sep 21 22:30:13 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345973, encodeId=4d503459e33f, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-22 zhaojie88

#清华#

32 0
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likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-21 西西er

期待

59 0
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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346054, encodeId=d409346054e3, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/10/b92c6fe1729451c8d4b3a5c04e1396c6.jpg, createdBy=dfe32402282, createdName=西西er, createdTime=Fri Sep 21 22:30:13 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345973, encodeId=4d503459e33f, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-21 kafei

学习学习谢谢

67 0
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channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66216, encryptionId=9e6866216d7, topicName=清华)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 22 15:15:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346054, encodeId=d409346054e3, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/10/b92c6fe1729451c8d4b3a5c04e1396c6.jpg, createdBy=dfe32402282, createdName=西西er, createdTime=Fri Sep 21 22:30:13 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345973, encodeId=4d503459e33f, content=学习学习谢谢, beContent=null, objectType=article, channel=null, level=null, 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content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-21 liumin1987

嗯嗯，优秀，赞一个。

54 0
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likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Fri Sep 21 08:17:43 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345945, encodeId=ffeb3459455b, content=嗯嗯，优秀，赞一个。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Fri Sep 21 07:52:36 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345935, encodeId=d7e734593576, content=优秀！所有努力付出获得的成果都值得我们学习的称赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Fri Sep 21 06:49:16 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
2018-09-21 太阳系小猪

优秀！所有努力付出获得的成果都值得我们学习的称赞

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