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SCIENCE：我国学者发现降低胆固醇吸收的遗传因素

2018-06-10 海北 MedSci原创

胆固醇遗传
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尽管我们已经知道LDL-C的水平因人而异，并且具有可遗传性，但至今为止，影响LDL-C的遗传因素尚未得到充分表征。

低密度脂蛋白胆固醇（LDL-C）水平的升高是心血管疾病的主要危险因素。尽管我们已经知道LDL-C的水平因人而异，并且具有可遗传性，但至今为止，影响LDL-C的遗传因素尚未得到充分表征。

最近，我国研究人员在来自中国哈萨克族家族的LIMA1基因（也称为EPLIN或SREBP3）中发现了一种罕见的移码突变，该突变的人群具有遗传性低LDL-C的水平和降低的胆固醇吸收。

在小鼠模型中，LIMA1主要在小肠中表达，并定位在刷状缘膜上。 LIMA1将NPC1L1（一种吸收胆固醇的必需蛋白质）桥接到含有肌球蛋白Vb的运输复合物上，并促进胆固醇摄取。与人的表型类似，Lima1缺陷型小鼠表现出降低的胆固醇吸收，并对饮食诱导的高胆固醇血症有抗性。

通过对小鼠和人类的研究，研究人员确定LIMA1是调节肠道胆固醇吸收的关键蛋白。


原始出处：

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    2019-04-20 fusion

    #我国学者#

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    2018-06-16 jihuaijun1112

    学习学习学习

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    2018-06-14 jihuaijun1112

    学习学习学习

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createdTime=Sun Jun 10 09:43:04 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323019, encodeId=c348323019c6, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sun Jun 10 09:35:52 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-11 jichang

    #SCIE#

    0

  5. 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    2018-06-11 wjcjjian

    #遗传因素#

    0

  6. 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    2018-06-10 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Jun 10 10:57:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323045, encodeId=a02e3230456f, content=降低肠道胆固醇吸收, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun Jun 10 10:55:19 CST 2018, time=2018-06-10, status=1, ipAttribution=), 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createdTime=Sun Jun 10 09:43:04 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323019, encodeId=c348323019c6, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sun Jun 10 09:35:52 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 lyh994

    降低肠道胆固醇吸收

    0

  8. 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    2018-06-10 131****1460

    学习了受益匪浅

    0

  9. 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createdTime=Sun Jun 10 09:43:04 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323019, encodeId=c348323019c6, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sun Jun 10 09:35:52 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 龙胆草

    学习谢谢分享

    0

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