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JAMA Pediatr：母婴同室成为新生儿戒断综合征首先治疗模式

2018-02-06 zhangfan MedSci原创

母婴同室新生儿戒断综合征阿片药物
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研究认为，因宫内阿片类药物暴露导致新生儿戒断综合征患儿，接受母婴同室治疗可减少药物使用和住院时间，应成为NAS治疗的首选模式

近年来因宫内阿片类药物暴露导致的新生儿戒断综合征(NAS)发病率呈上升趋势。传统上，NAS新生儿需接受重症监护 (NICU)。近日研究人员考察了NAS新生儿母婴同室对减少药物治疗、住院时间(LOS)和费用的效果。

研究人员对截止2017年6月25日MEDLINE， CINAHL， The Cochrane Library以及clinicaltrials.gov的相关研究资料进行考察。主要终点是新生儿药物治疗，次要终点包括LOS、住院花费和不良事件等。

有6个相关研究纳入本次分析，总计549名患儿。研究发现，母婴同室相比于NICU治疗在减少药物治疗的使用(RR，0.37；95% CI，0.19-0.71；I2=85%)和住院时间(时间减少，-10.41天；95% CI，-16.84到-3.98天；I2=91%)方面更具优势。敏感性分析显著母婴同室对减少患儿治疗方面更具优势 (RR，0.32；95% CI，0.18-0.57；I2=13%)。定量分析显示，母婴同室在提高母乳喂养率，降低家庭监护风险方面更具优势，但对于住院期间不良事件及再住院率无显著影响。

研究认为，因宫内阿片类药物暴露导致新生儿戒断综合征患儿，接受母婴同室治疗可减少药物使用和住院时间，应成为NAS治疗的首选模式。

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    2018-05-26 feather89

    #PE#

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    2018-05-04 ms3323097325231039

    #戒断综合征#

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    2018-06-27 124987e8m07暂无昵称

    #母婴同室#

    0

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style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 23 13:08:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431108, encodeId=f4e814311084a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439371, encodeId=1c8614393e1b7, content=<a href='/topic/show?id=45616352128' target=_blank style='color:#2F92EE;'>#母婴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63521, encryptionId=45616352128, topicName=母婴)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555150, encodeId=9125155515083, content=<a href='/topic/show?id=b9c0646602d' target=_blank style='color:#2F92EE;'>#治疗模式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64660, encryptionId=b9c0646602d, topicName=治疗模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12b614593183, createdName=yankaienglish, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285891, encodeId=9d3828589193, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Feb 07 08:38:03 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285660, encodeId=c46a2856602e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Feb 06 13:41:21 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-08-23 ms9608593228839890

    #DIA#

    0

  5. 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createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439371, encodeId=1c8614393e1b7, content=<a href='/topic/show?id=45616352128' target=_blank style='color:#2F92EE;'>#母婴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63521, encryptionId=45616352128, topicName=母婴)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555150, encodeId=9125155515083, content=<a href='/topic/show?id=b9c0646602d' target=_blank style='color:#2F92EE;'>#治疗模式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64660, encryptionId=b9c0646602d, topicName=治疗模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12b614593183, createdName=yankaienglish, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285891, encodeId=9d3828589193, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Feb 07 08:38:03 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285660, encodeId=c46a2856602e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Feb 06 13:41:21 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-08 zhouqu_8

    #综合征#

    0

  6. 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style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 23 13:08:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431108, encodeId=f4e814311084a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439371, encodeId=1c8614393e1b7, content=<a href='/topic/show?id=45616352128' target=_blank style='color:#2F92EE;'>#母婴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63521, encryptionId=45616352128, topicName=母婴)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555150, encodeId=9125155515083, content=<a href='/topic/show?id=b9c0646602d' target=_blank style='color:#2F92EE;'>#治疗模式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64660, encryptionId=b9c0646602d, topicName=治疗模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12b614593183, createdName=yankaienglish, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285891, encodeId=9d3828589193, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Feb 07 08:38:03 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285660, encodeId=c46a2856602e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Feb 06 13:41:21 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-08 zhouqu_8

    #母婴#

    0

  7. 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style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 23 13:08:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431108, encodeId=f4e814311084a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439371, encodeId=1c8614393e1b7, content=<a href='/topic/show?id=45616352128' target=_blank style='color:#2F92EE;'>#母婴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63521, encryptionId=45616352128, topicName=母婴)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555150, encodeId=9125155515083, content=<a href='/topic/show?id=b9c0646602d' target=_blank style='color:#2F92EE;'>#治疗模式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64660, encryptionId=b9c0646602d, topicName=治疗模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12b614593183, createdName=yankaienglish, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285891, encodeId=9d3828589193, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Feb 07 08:38:03 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285660, encodeId=c46a2856602e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Feb 06 13:41:21 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-08 yankaienglish

    #治疗模式#

    0

  8. 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style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 23 13:08:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431108, encodeId=f4e814311084a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439371, encodeId=1c8614393e1b7, content=<a href='/topic/show?id=45616352128' target=_blank style='color:#2F92EE;'>#母婴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63521, encryptionId=45616352128, topicName=母婴)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555150, encodeId=9125155515083, content=<a href='/topic/show?id=b9c0646602d' target=_blank style='color:#2F92EE;'>#治疗模式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64660, encryptionId=b9c0646602d, topicName=治疗模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12b614593183, createdName=yankaienglish, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285891, encodeId=9d3828589193, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Feb 07 08:38:03 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285660, encodeId=c46a2856602e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Feb 06 13:41:21 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-07 flysky120

    学习一下知识了

    0

  9. 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level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64660, encryptionId=b9c0646602d, topicName=治疗模式)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12b614593183, createdName=yankaienglish, createdTime=Thu Feb 08 04:08:00 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285891, encodeId=9d3828589193, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Feb 07 08:38:03 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285660, encodeId=c46a2856602e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Feb 06 13:41:21 CST 2018, time=2018-02-06, status=1, ipAttribution=)]
    2018-02-06 smartxiuxiu

    好

    0

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