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Tuberc Respir Dis：加巴喷丁治疗慢性咳嗽的疗效和安全性

2018-07-30 MedSci MedSci原创

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尽管最近公布了临床指南，但是难治性慢性咳嗽的最佳治疗策略仍然是一个挑战。本系统评价旨在评估加巴喷丁治疗慢性咳嗽的疗效和安全性。检索PubMed，Embase，Cochrane图书馆数据库和出版物。两位评价者根据研究选择的先验标准搜索文章。共确定了7篇相关文章，包括2项随机对照试验，1项连续患者设计的前瞻性病例系列，1例连续患者的回顾性病例系列，1例未知连续状态的回顾性病例系列，2例病例报告，分别包

尽管最近公布了临床指南，但是难治性慢性咳嗽的最佳治疗策略仍然是一个挑战。本系统评价旨在评估加巴喷丁治疗慢性咳嗽的疗效和安全性。

检索PubMed，Embase，Cochrane图书馆数据库和出版物。两位评价者根据研究选择的先验标准搜索文章。

共确定了7篇相关文章，包括2项随机对照试验，1项连续患者设计的前瞻性病例系列，1例连续患者的回顾性病例系列，1例未知连续状态的回顾性病例系列，2例病例报告，分别包括了6例和2例患者。

结果显示，在随机对照试验中使用加巴喷丁治疗后，患者在咳嗽特异性生活质量（莱斯特咳嗽问卷评分）和咳嗽严重程度（视觉模拟评分）方面得到改善。前瞻性病例系列结果显示，使用巴喷丁治疗，咳嗽和感觉神经病变的总体改善率为68％。与安慰剂或标准药物相比，加巴喷丁治疗慢性咳嗽患者的疗效和安全性良好。但是仍需要进一步的随机和对照试验。

原始出处：

Shi G, Shen Q, et al., Efficacy and Safety of Gabapentin in the Treatment of Chronic Cough: A Systematic Review. Tuberc Respir Dis (Seoul). 2018 Jul;81(3):167-174. doi: 10.4046/trd.2017.0089. Epub 2018 Jun 19.

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    2019-06-12 cmj8wellington

    #Dis#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2012758, encodeId=5b032012e58fd, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Jun 12 06:46:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720868, encodeId=b8691e2086801, content=<a href='/topic/show?id=634ee040179' target=_blank style='color:#2F92EE;'>#疗效和安全性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70401, encryptionId=634ee040179, topicName=疗效和安全性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ef32982072, createdName=经常头晕, createdTime=Thu Jul 04 03:46:00 CST 2019, time=2019-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335221, encodeId=359b33522153, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Tue Jul 31 04:04:08 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335062, encodeId=43c93350623c, content=学习了学习了，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Mon Jul 30 07:40:30 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335028, encodeId=088b335028da, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Jul 30 06:04:28 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031859, encodeId=81d61031859d1, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Jul 30 04:46:00 CST 2018, time=2018-07-30, status=1, ipAttribution=)]
    2019-07-04 经常头晕

    #疗效和安全性#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2012758, encodeId=5b032012e58fd, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Jun 12 06:46:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720868, encodeId=b8691e2086801, content=<a href='/topic/show?id=634ee040179' target=_blank style='color:#2F92EE;'>#疗效和安全性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70401, encryptionId=634ee040179, topicName=疗效和安全性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ef32982072, createdName=经常头晕, createdTime=Thu Jul 04 03:46:00 CST 2019, time=2019-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335221, encodeId=359b33522153, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Tue Jul 31 04:04:08 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335062, encodeId=43c93350623c, content=学习了学习了，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Mon Jul 30 07:40:30 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335028, encodeId=088b335028da, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Mon Jul 30 06:04:28 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031859, encodeId=81d61031859d1, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Jul 30 04:46:00 CST 2018, time=2018-07-30, status=1, ipAttribution=)]
    2018-07-31 青山颖钰

    学习了

    0

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    2018-07-30 phoebeyan520

    学习了学习了，感谢

    0

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    2018-07-30 yjs木玉

    好好好好好好好好

    0

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    2018-07-30 内科新手

    谢谢梅斯提供这么好的信息，学到很多

    0