Ann Rheum Dis:不同脊柱关节炎亚型的心律紊乱和主动脉瓣返流风险

2017-12-20 xiangting MedSci原创

SpA患者出现主动脉瓣返流、心律紊乱的风险升高,并且作为可能的结果,PM的风险也升高。

这项研究旨在描述与普通人群(GP)相比,强直性脊柱炎(AS)、未分化脊柱关节炎(uSpA)和银屑病关节炎(PsA)患者房室传导阻滞(AV II-III)、房颤(AF)、起搏器植入(PM)和主动脉瓣返流的发病率。

这是一项前瞻性的全国研究,纳入2001 - 2009年间瑞典全国患者和人口登记的AS队列(n = 6448)、PsA队列(n = 16 063)、uSpA队列(n = 5190)和GP队列(n = 2 66435)。随访从2006年1月1日开始,到2012年12月31日或事件、死亡、移民而结束。计算年龄标准化和性别标准化的发病率和风险比(HRs)。

AF的发生率最高(每1000人年5.5-7.4事件),其次是PM(每1000人年1.0-2.0事件)。与GP队列相比,AS(HRs 2.3,1.3,2.1和1.9),uSpA(HRs 2.9,1.3,1.9和2.0)和PsA(HR 1.5,1.5,1.6和1.8)的AV阻滞、AF、PM和主动脉瓣返流的HRs显著升高。与GP相比,男性uSpA(HR 4.2)和AS(HR 2.5)患者房室传导阻滞的HRs最高。与PsA相比,AS中PM(HR 1.5)和uSpA中AV阻滞(HR 1.8)的HRs显著升高。

SpA患者出现主动脉瓣返流、心律紊乱的风险升高,并且作为可能的结果,PM的风险也升高。最常见的心律失常尤其是房颤,需要提高警惕,而对AS或uSpA的男性需要警惕房室传导阻滞。

原始出处:

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    2017-12-22 lmm397
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objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Dec 20 16:55:20 CST 2017, time=2017-12-20, status=1, ipAttribution=)]
    2017-12-21 戒馋,懒,贪

    谢谢分享学习了

    0

  8. 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content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 20 20:54:58 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270959, encodeId=32af2e09599a, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Dec 20 17:54:30 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270951, encodeId=84a72e09513c, content=学习了.感谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Dec 20 16:55:20 CST 2017, time=2017-12-20, status=1, ipAttribution=)]
    2017-12-20 三生有幸9135

    学习一下谢谢分享

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23207, encryptionId=2c0c2320e17, topicName=主动脉瓣返流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59014291869, createdName=snowpeakxu, createdTime=Fri Dec 22 05:59:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271284, encodeId=2aa02e128475, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Thu Dec 21 19:30:23 CST 2017, time=2017-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270995, encodeId=fa482e099544, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 20 20:54:58 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270959, encodeId=32af2e09599a, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Dec 20 17:54:30 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270951, encodeId=84a72e09513c, content=学习了.感谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Dec 20 16:55:20 CST 2017, time=2017-12-20, status=1, ipAttribution=)]
    2017-12-20 thlabcde

    好资料学习了!

    0

  10. 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content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Dec 20 20:54:58 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270959, encodeId=32af2e09599a, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Dec 20 17:54:30 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270951, encodeId=84a72e09513c, content=学习了.感谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Dec 20 16:55:20 CST 2017, time=2017-12-20, status=1, ipAttribution=)]
    2017-12-20 1e0f8808m18(暂无匿称)

    学习了.感谢分享.

    0

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