Cornea:体内共焦显微镜显示神经营养性角膜病变后角膜神经细胞再生情况!

2017-10-26 cuiguizhong MedSci原创

加拿大多伦多大学儿童医院眼科与视力科学系的Fung SSM近日在Cornea杂志上发表了他们近期的一项工作,他们对2例神经营养性角膜病变(NK)患者进行角膜神经细胞再生手术,使用体内共聚焦显微镜(IVCM),记录了角膜上新感觉神经纤维的存在位置。

加拿大多伦多大学儿童医院眼科与视力科学系的Fung SSM近日在Cornea杂志上发表了他们近期的一项工作,他们对2例神经营养性角膜病变(NK)患者进行角膜神经细胞再生手术,使用体内共聚焦显微镜(IVCM),记录了角膜上新感觉神经纤维的存在位置。

两名单侧先天神经营养性角膜病变患者接受了角膜神经刺激手术,促使角膜再融合。使用体内共聚焦显微镜(IVCM)来鉴别鼻下神经纤维,并记录角膜神经再生。在1例患者(病例1)中,IVCM在角膜神经再生前后分别进行。在第二例患者(病例2)中,IVCM在神经细胞再生和角膜移植后进行。

分析结果,他们发现,在病例1中,使用氰基丙烯酸酯胶合进行角膜穿孔。由于神经营养性角膜病变相关的角膜穿孔,患者具有运动视力,术前IVCM没有发现鼻旁神经。然而,在角膜神经细胞再生后6个月,发现鼻旁神经的存在,同时没有发现存在上皮缺陷。在病例2中,患者基底脑膜脑膜瘤经过治疗导致角膜感觉完全不存在。在角膜神经细胞再生后角膜感觉、视力和眼表面健康状况得到改善。在角膜感觉重新建立两年半后,进行角膜移植术。 体内共聚焦显微镜(IVCM)显示,在基质和基底层水平上的角膜再生模式与正常角膜模式不同。

因此,他们认为,角膜神经细胞通过增强角膜的基质和底层来恢复角膜感觉。在这样做时,角膜神经再生可能会阻止神经营养性角膜病变的过程,并进一步防止视力丧失。

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    2018-07-09 tulenzi
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    2017-10-28 snowpeakxu
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    2017-10-27 方舒

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