J Clin Periodontol: 衰老对慢性牙周炎体液免疫反应的影响

2018-06-30 MedSci MedSci原创

牙周病是一种随着年龄增长发病率增加的全球性感染疾病。本实验着重于牙周炎中的宿主适应性免疫应答。

牙周病是一种随着年龄增长发病率增加的全球性感染疾病。本实验着重于牙周炎中的宿主适应性免疫应答。虽然患有牙周炎的实验模型和患者表现出对特定口腔细菌的抗原特异性,但是我们对以下几方面了解有限,(i)这些细菌在疾病表达前数十年长期定植于口腔,老龄化如何影响这些细菌的适应性免疫应答。ii)在疾病恶化期间,这种反应与细菌生态中出现的病原体的程度和特异性如何。

实验纳入21至74岁人群,基于其牙周组织的临床状态,吸烟和性别进行分层,并测量个体口腔致病菌和共生菌的血清抗体水平。

结果:在与年龄相关的健康,牙龈炎或牙周炎组中,临床参数没有显着差异。在每个临床类别中,不同年龄组的口腔病原体和共生菌抗体相似,牙周炎患者没有发现年龄相关性。

对长期定植于口腔的细菌的适应性免疫应答一般不受年龄影响,但其与疾病程度有关。

原始出处:

Jeffrey L, et al. Ageing effects on humoral immune responses in chronic periodontitis. Journal of Clinical Periodontology. 2018 June. doi:10.1111/jcpe.12881

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    2018-07-05 feather89
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    2018-07-02 三生有幸9135

    学习一下

    0

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08:30:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328145, encodeId=22dd328145bf, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 30 07:58:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328138, encodeId=aace32813852, content=学习了!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jun 30 07:52:59 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328129, encodeId=8d8c32812987, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 30 07:31:04 CST 2018, time=2018-06-30, status=1, ipAttribution=)]
    2018-06-30 sunfeifeiyang

    0

  8. 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08:30:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328145, encodeId=22dd328145bf, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 30 07:58:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328138, encodeId=aace32813852, content=学习了!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jun 30 07:52:59 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328129, encodeId=8d8c32812987, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 30 07:31:04 CST 2018, time=2018-06-30, status=1, ipAttribution=)]
    2018-06-30 龙胆草

    学习谢谢分享

    0

  9. 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08:30:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328145, encodeId=22dd328145bf, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 30 07:58:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328138, encodeId=aace32813852, content=学习了!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jun 30 07:52:59 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328129, encodeId=8d8c32812987, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 30 07:31:04 CST 2018, time=2018-06-30, status=1, ipAttribution=)]
    2018-06-30 zb1235672

    学习了!!!!

    0

  10. 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08:30:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328145, encodeId=22dd328145bf, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 30 07:58:29 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328138, encodeId=aace32813852, content=学习了!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jun 30 07:52:59 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328129, encodeId=8d8c32812987, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 30 07:31:04 CST 2018, time=2018-06-30, status=1, ipAttribution=)]
    2018-06-30 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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最近,有研究人员确定了2006年到2015年10年之间,是否在关于年龄相关听力损失的基础和临床前研究中存在性别偏差,这要比NIH授权将性别包括在生物变量中的时间-2016年要更早。研究人员在PubMed中搜索了"年龄相关听力损失"关键词的相关文章,时间为2006年到2015年。研究只包括了原始研究(不包括综述或者元分析),并且是英语文章,包括摘要,使用动物模型且是主要与年龄相关听力损失相关。上述标

Eur Respir J:年龄和合并症对特发性肺动脉高压危险分层的影响!

由此可见,除了已建立的风险评估算法之外,这些发现强调了年龄和特定合并症作为IPAH患者结局预后标记的重要性。

J Clin Periodontol: 日常吸烟者牙周状况与营养饮食的关系

本实验旨在验证健康饮食是否与吸烟者的牙周状况相关。

Stroke:急性缺血性卒中患者血管内治疗的疗效取决于年龄和严重程度!

由此可见,在SC评分分层的患者中,EVT与老年和更严重患者的功能改善相关,而在年轻和不严重的患者中与其无关。

Natr Human Behav:年龄越大,为什么越来越不容易集中?

我们都知道,在日常出现的无关紧要信息,甚至是经历压力或强烈情感时,年龄大的人比年轻人更容易分心。近日,美国南加州大学(USC)主导的一项研究,阐明了其中的缘由:大脑中一个特定网络是导致该现象的原因,而这也是阿尔兹海默症和痴呆症的“震中”位置。这项研究于近日已发表在《Nature Human Behavior》上。

J Dent Res:年龄对于口腔癌的疾病进程和微环境的影响

尽管现代医院已经认识到年龄与癌症存在一定的联系,但是大多数实验性肿瘤模型的临床前试验也仅是在6-8周龄的啮齿类动物体内展开。这篇研究的目的是为了检测年龄对头颈鳞状细胞癌(HNSCC)小鼠模型肿瘤发生率、生长和微环境特征的影响。