Lancet Neurol:爆炸伤后患者出现的特发颅脑损伤

2016-06-17 MedSci MedSci原创

研究人员首次发现爆炸伤后患者出现的特殊脑损伤,这有助于解释患者遭受爆炸伤后出现的相关临床表现及帮助诊断和治疗。 马里兰州贝塞斯达大学的Daniel P. Perl博士指出,某些患者在经历爆炸伤数年后仍表现出神经和行为症状,包括失眠、注意力不集中、头痛、短期记忆力减退或丧失、平衡障碍、焦虑和抑郁等问题。但是直到现在通过所有成像检查或生物标记物检测都不得解释其中的问题及脑损伤的客观证据,因此被称为无形

研究人员首次发现爆炸伤后患者出现的特殊脑损伤,这有助于解释患者遭受爆炸伤后出现的相关临床表现及帮助诊断和治疗。 


马里兰州贝塞斯达大学的Daniel P. Perl博士指出,某些患者在经历爆炸伤数年后仍表现出神经和行为症状,包括失眠、注意力不集中、头痛、短期记忆力减退或丧失、平衡障碍、焦虑和抑郁等问题。但是直到现在通过所有成像检查或生物标记物检测都不能解释其中的问题及脑损伤的客观证据,因此被称为无形的伤口。 

研究人员指出,他们已经发现了患者经历爆炸伤后不同于普通脑损伤的相关损害表现,他们相信在不久的将来爆炸伤导致民众出现的颅脑损伤终将变为可视伤口,并有助于医生更好地确立诊断和治疗。研究结果发表在The Lancet Neurology。

Perl博士和同事对8名爆炸袭击后幸存的男性军人颅脑组织进行了调查和评估,有3人在爆炸袭击后抢救无效死亡,其余5人幸存时间达6个月以上 。通过对5人的颅脑组织进行评估后,他们发现了一个独特的、一致的现象:单纯区周围有星形胶质细胞疤痕覆盖。

Perl博士指出,死亡的两名患者在爆炸后4天死亡,大脑组织显示出早期有星形胶质细胞瘢痕形成。早期出现卒中的患者大脑中也有星形胶质细胞瘢痕形成,但是形成位置不同。 

研究人员将其与普通男性民众的大脑进行比较,其中包括5名车祸或运动发生脑损伤的患者、5名吸食鸦片的民众和3名没有神经功能紊乱的民众的颅脑组织。在这些民众的颅脑组织中未发现相似的表现。 

Perl博士指出,遭受爆炸伤后患者会在单纯区形成特定的星形胶质细胞瘢痕,这可能是由于爆炸产生的高压冲击波所致,但是他们表示仍需进行更进一步的研究以探究爆炸伤后患者受损颅脑组织的恢复情况。

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    2016-07-28 yinhl1978
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    2016-10-12 ylzr123

    好文,值得推荐。

    0

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    2016-09-02 doctorJiangchao

    继续学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1999698, encodeId=959b1999698c2, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jul 28 04:19:00 CST 2016, time=2016-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146889, encodeId=13fd14688997, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Oct 12 16:06:29 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=109737, encodeId=b818109e37c5, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Fri Sep 02 14:39:00 CST 2016, time=2016-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=109738, encodeId=ac4d109e38c1, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Fri Sep 02 14:39:00 CST 2016, time=2016-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828519, encodeId=065c1828519ad, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Feb 01 03:19:00 CST 2017, time=2017-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379944, encodeId=ed2213e99446e, content=<a href='/topic/show?id=5f3c10046499' target=_blank style='color:#2F92EE;'>#颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100464, encryptionId=5f3c10046499, topicName=颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Sun Jun 19 03:19:00 CST 2016, time=2016-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397025, encodeId=fee7139e02535, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Jun 19 03:19:00 CST 2016, time=2016-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502966, encodeId=df661502966c7, content=<a href='/topic/show?id=7c606e37540' target=_blank style='color:#2F92EE;'>#爆炸伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67375, encryptionId=7c606e37540, topicName=爆炸伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98369588750, createdName=lg.zhao, createdTime=Sun Jun 19 03:19:00 CST 2016, time=2016-06-19, status=1, ipAttribution=)]
    2016-09-02 doctorJiangchao

    继续关注

    0

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    2017-02-01 howi
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    2016-06-19 lg.zhao