JCLA:血浆置换治疗高甘油三酯血症:血液粘度与甘油三酯清除率的关系

2019-07-12 Gladiator MedSci原创

双过滤血浆置换(DFPP)中几个因素与甘油三酯(TG)清除率有关。本研究检验基线全血粘度是否可作为有效去除TG的预测因子。 研究人员将2015年1月至2018年3月在桃园总医院接受DFPP治疗高脂血症的成人受试者,按TG去除率≥50% vs <50%分为有效和无效两组。TG去除率定义为:(pre - apheresis TG‐post - apheresis TG)/pre - aph

双过滤血浆置换(DFPP)中几个因素与甘油三酯(TG)清除率有关。本研究检验基线全血粘度是否可作为有效去除TG的预测因子。

研究人员将20151月至20183月在桃园总医院接受DFPP治疗高脂血症的成人受试者,按TG去除率≥50% vs <50%分为有效和无效两组。TG去除率定义为:(pre - apheresis TGpost - apheresis TG)/pre - apheresis TG。全血粘度(WBV)计算公式为:WBV = 0.12×红细胞压积+0.17×(总蛋白- 2.07)。采用单变量线性回归分析了甘油三酯去除率与WBV的关系。采用logistic回归模型对各变量与有效TG去除之间的关系进行优势比(ORs)95%置信区间(95% ci)评价,纳入单变量和多变量调整。

研究发现,在接受DFPP治疗的66名受试者中,37名受试者达到了有效的TG去除。高效与低效TG去除组之间的产前TG、红细胞压积和WBV差异为4.1 mmol/L6.7 mmol/L;43.1%39.5%6.0cP vs 5.cP (Ps <0.05)。多元校正后,WBC是有效去除TG的显著预测因子(or95% CI分别为3.192(1.3007.838)P < 0.05)WBVTG提取的相关性显著(r = - 0.255, P = 0.039)

研究表明,高粘度降低了接受DFPP的去除TG效率。

原始出处:

HungChieh Wu,  LinChien Lee ,Plasmapheresis for hypertriglyceridemia: The association between blood viscosity and triglyceride clearance rate

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    2020-03-06 jyzxjiangqin

    双过滤血浆置换。

    0

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    2020-02-19 jyzxjiangqin

    高甘油三酯血症。

    0

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    2019-12-20 yxch48
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    2019-08-05 jyzxjiangqin

    高甘油三酯血症患者的治疗。

    0

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