Clinica Chimica Acta:血清激活素和follistatin在异位妊娠诊断中的作用

2020-02-18 MedSci MedSci原创

目前,对于异位妊娠(EP)的诊断具有一定难度,约40-50%的患者会最初被误诊。

目前,对于异位妊娠(EP)诊断具有一定难度,约40-50%的患者会最初被误诊。

本前瞻性病例对照研究分析了激活素- a、激活素- b、激活素- abfollistatinEP、自然流产(SAB)和正常宫内妊娠(IUP)诊断价值。收集120个女性怀孕早期失败的症状和临床诊断为IUP, SABEP (n = 40 /) 血清。采用ELISA法测定标记物的曲线下面积(AUC)、截断值、敏感性和特异性由受试者操作特征曲线确定。结果与血清β-human绒毛膜促性腺激素和孕激素。

研究结果显示,与IUP组相比,EP组和SAB组的激活素- a和激活素- b显著降低,而激活素- abfollistatin升高。激活素-ABAUC = 0.961)和孕激素(AUC = 0.973)分别是EPSAB的最佳标记。 Activin-AB≥61.5μpg/ mL)对EP表现出92.5%的敏感性,85%的特异性,75.5%的阳性预测值(PPV)和95.8%的阴性预测值(NPV)。 黄体酮(≤6.3ng / mL)对SAB的敏感性为100%,特异性为86.2%,PPV78.4%,NPV100%。

研究结果表明,血清激活素和follistatinEP呈显著性变化,而激活素抗体可能是EP诊断的一个有前景的标志物。

原始出处:

Bassem RefaatAdil O. BahathiqThe performances of serum activins and follistatin in the diagnosis of ectopic pregnancy: A prospective case-control study

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    2020-06-03 DEXTER3139
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    2020-05-26 snowpeakxu
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    2020-06-03 windight
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