J Gastroenterology：黏膜 IL23A 表达水平可预测炎症性肠病对乌司奴单抗的反应

2021-10-03 MedSci原创 MedSci原创

炎症性肠病 (IBD) 包括溃疡性结肠炎 (UC) 和克罗恩病 (CD)，是一种难治性的胃肠道的慢性炎症。

炎症性肠病 (IBD) 包括溃疡性结肠炎 (UC) 和克罗恩病 (CD)，是一种难治性的胃肠道的慢性炎症。IBD 被认为是一种多因素导致的疾病，其发病机制尚不清楚。过多的肠黏膜内的免疫细胞激活是活动性 IBD 的标志。单克隆抗体的引入抑制炎症已经大大改变了 IBD治疗策略。乌司奴单抗 (UST) 是最近开发的单克隆抗体，其靶向白细胞介素 (IL)-12 和 IL-23 的 p40 亚基。在此，本项研究旨在确定 IBD 治疗反应预测的因素。

研究人员对 33 名 IBD 受试者进行了一项针对抗 TNF 的回顾性研究，并对 23 名 IBD 和 11 名非 IBD 受试者进行了一项针对乌司奴单抗 (UST) 的前瞻性研究。研究人员对所有患者在使用生物制剂治疗之前进行了粘膜活检的获取。然后通过定量聚合酶链反应分析了 18 个编码代表性细胞因子和转录因子的免疫相关基因的表达。

研究结果表明就临床特征而言，治疗抵抗组和敏感组之间没有差异。肠黏膜中制瘤素 M (OSM) 及其受体 OSMR 的较高表达与抗 TNF 抗性最密切相关，而较低的 IL23A 表达与 UST 抗性最密切相关。除了基因的绝对表达水平外，特定基因组的一致或不一致表达模式也与治疗敏感性和耐药性相关。

本项研究结果证实抗 TNF 耐药性与粘膜 OSM 和 OSMR 表达存在明显相关性。而且研究人员还观察到具有较高黏膜 IL23A 表达的 IBD 受试者更有可能通过 UST 实现缓解，这一点以前没有研究报道过。因此，可以通过分析粘膜基因表达水平和模式来预测 IBD 患者对生物制剂的反应。

原始出处：

Kei Nishioka. Et al. Mucosal IL23A expression predicts the response to Ustekinumab in inflammatory bowel disease. Journal of Gastroenterology.2021.

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2022-05-20 赛华佗

#乌司奴单抗#与#炎症性肠病#

84 0
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2021-11-03 医者仁心

#Gastroenterol#

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2022-03-22 wetgdt

#表达水平#

41 0
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2022-03-09 ms24272190615788285182

#AST#

29 0
[GetPortalCommentsPageByObjectIdResponse(id=1221232, encodeId=ade31221232c5, content=<a href='/topic/show?id=b92d233416b' target=_blank style='color:#2F92EE;'>#乌司奴单抗#</a>与<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23341, encryptionId=b92d233416b, topicName=乌司奴单抗), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Fri May 20 17:16:30 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065451, encodeId=e9272065451f9, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Nov 03 16:47:10 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990185, encodeId=c9bc199018537, content=<a href='/topic/show?id=c6c0902e456' target=_blank style='color:#2F92EE;'>#表达水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90274, encryptionId=c6c0902e456, topicName=表达水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Tue Mar 22 21:47:10 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712940, encodeId=65ee1e12940f3, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Mar 09 22:47:10 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073452, encodeId=dfd220e345206, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Sep 11 17:47:10 CST 2022, time=2022-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505330, encodeId=0f801505330ec, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 05 06:47:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520086, encodeId=022615200866f, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Oct 05 06:47:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547480, encodeId=da5d154e4808c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Oct 05 06:47:10 CST 2021, time=2021-10-05, status=1, ipAttribution=)]
2022-09-11 许安

#GAS#

31 0
[GetPortalCommentsPageByObjectIdResponse(id=1221232, encodeId=ade31221232c5, content=<a href='/topic/show?id=b92d233416b' target=_blank style='color:#2F92EE;'>#乌司奴单抗#</a>与<a href='/topic/show?id=2e6e6e0315d' target=_blank style='color:#2F92EE;'>#炎症性肠病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23341, encryptionId=b92d233416b, topicName=乌司奴单抗), TopicDto(id=67031, encryptionId=2e6e6e0315d, topicName=炎症性肠病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Fri May 20 17:16:30 CST 2022, time=2022-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065451, encodeId=e9272065451f9, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Nov 03 16:47:10 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990185, encodeId=c9bc199018537, content=<a href='/topic/show?id=c6c0902e456' target=_blank style='color:#2F92EE;'>#表达水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90274, encryptionId=c6c0902e456, topicName=表达水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Tue Mar 22 21:47:10 CST 2022, time=2022-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712940, encodeId=65ee1e12940f3, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Mar 09 22:47:10 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073452, encodeId=dfd220e345206, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Sep 11 17:47:10 CST 2022, time=2022-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505330, encodeId=0f801505330ec, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 05 06:47:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520086, encodeId=022615200866f, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Tue Oct 05 06:47:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547480, encodeId=da5d154e4808c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Oct 05 06:47:10 CST 2021, time=2021-10-05, status=1, ipAttribution=)]
2021-10-05 chaojitidian

#Gastroenterology#

31 0
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2021-10-05 snowpeakxu

#黏膜#

41 0
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2021-10-05 12498dd9m15暂无昵称

#炎症性#

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J Gastroenterology：黏膜 IL23A 表达水平可预测炎症性肠病对乌司奴单抗的反应

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