Neurology:现代影像学时代脑血管事件的急诊科误诊率如何?

2017-03-31 xing.T MedSci原创

大约9%的脑血管事件在初次ED就诊时没有发现。当出现神经系统症状较轻微、非特异性或暂时性时,误诊的风险要大得多(范围为24%-60%)。这种差异表明很多误诊与症状特异性因素相关。对于误诊风险最大的症状特异性亚群,未来的研究应强调研究的原因和设计减少误诊的策略。

急诊科(ED)是误诊风险较高的科室,近日,神经病学领域权威取杂志Neurology上发表了一篇荟萃分析文章,研究人员试图估计ED识别急性脑血管事件的诊断准确性。

研究人员检索了MEDLINE和Embase数据库,查找报告了缺血性脑卒中、TIA或蛛网膜下腔出血(SAH)ED诊断准确性的研究(1995-2016)。两位独立审稿人确定纳入的研究。研究人员找到了1693个独特的引文,查阅了214篇文献全文,并分析了23项研究。研究被根据偏倚风险(QUADAS-2)进行排列,提取诊断数据。研究人员前瞻性地定义了临床表现亚群来比较误诊率。

纳入的研究报告15721例患者,研究的偏倚风险较低。脑血管病因的整体敏感性(91.3%(95%可信区间(CI)为90.7-92])和特异性(92.7%[91.7-93.7])较高,但是根据临床表现,有显著的变化。研究人员发现在症状较轻(正常与不正常的精神状态的SAH;假阴性率为23.8% vs. 4.2%,比值比[OR]为7.03 [4.8-10.31])、非特异性(头晕与运动表现;假阴性率为39.4% vs. 4.4%,OR为14.22[9.76-20.74])或短暂(TIA与缺血性脑卒中;错误发现率为59.7% vs. 11.7%,OR为11.21[6.66-18.89])的亚群中误诊更加常见。

大约9%的脑血管事件在初次ED就诊时没有发现。当出现神经系统症状较轻微、非特异性或暂时性时,误诊的风险要大得多(范围为24%-60%)。这种差异表明很多误诊与症状特异性因素相关。对于误诊风险最大的症状特异性亚群,未来的研究应强调研究的原因和设计减少误诊的策略。

原始出处:


Alexander Andrea Tarnutzer,et al. ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging. Neurology. 2017. http://www.neurology.org/content/early/2017/03/29/WNL.0000000000003814.short

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    2017-05-08 yinhl1978
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    2017-04-03 天涯183

    非常好的文章,学习了

    0

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    2017-04-01 天涯183

    非常好的研究

    0

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    2017-04-01 baihao215

    有意思,也有意义

    0

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    2017-03-31 1ddf0692m34(暂无匿称)

    减少误诊,抢救生命

    0

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    2017-03-31 milkshark

    这篇写的非常不错

    0

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