NEJM:血压控制——强化降压治疗vs标准降压治疗

2017-08-24 zhangfan MedSci原创

对于高血压和心血管疾病风险增加的非糖尿病患者,强化降压治疗与标准降压治疗对患者临床结果差异不显著,患者的血压控制、生理或认知功能均保持稳定

先前的研究表明,对于高血压和心血管疾病风险增加的非糖尿病受试者,强化降压治疗(收缩压<120mmHg)相比于常规降压治疗(收缩压<140mmHg)可显著降低患者的心血管事件发生率,近日研究人员公布了该研究的最终患者临床结果。研究招募了9361名患者,随机接受强化降压治疗或常规降压治疗。患者临床终点评分方法包括身体机能评分(PCS)、心理机能评分(MCS)、患者抑郁状态评分(PHQ-9)、血压控制和降压药物依从性满意度。强化治疗组患者平均服用1种抗高血压药物,收缩压较标准治疗组低14.8mmHg(95% CI,14.3-15.4)。PCS, MCS以及PHQ-9平均分数在3年的随访中保持稳定,组间无显著差异。组间生理或认知功能分数无显著差异。两组血压控制的满意度较高,降压药物的患者依从性无显著差异。研究发现,对于高血压和心血管疾病风险增加的非糖尿病患者,强化降压治疗与标准降压治疗对患者临床结果差异不显著,患者的血压控制、生理或认知功能均保持稳定。原始出处:Dan R. Berlowitz et al. Effect of Intensive Blood-Pressure Tr

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