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J Mater Sci Mater Med：壳聚糖支架结合辛伐他汀负载纳米粒子引导骨再生

2019-04-28 不详 网络

关注

本研究旨在探究制备和表征壳聚糖与不同量的辛伐他汀负载纳米粒子的组合，并研究它们在体外和体内引导骨再生的潜力。将不同的SIM-CSN制剂组合成壳聚糖支架（SIM-CSNs-S），并研究形态学，辛伐他汀释放曲线以及对细胞增殖和分化的影响。对于体内实验，选择SD大鼠的异位成骨和临界尺寸颅骨缺损模型来评估骨再生潜力。所有三种SIM-CSNs-S制剂都具有多孔结构并且表现出持续的辛伐他汀释放。CSNs-S显

本研究旨在探究制备和表征壳聚糖与不同量的辛伐他汀负载纳米粒子的组合，并研究它们在体外和体内引导骨再生的潜力。

将不同的SIM-CSN制剂组合成壳聚糖支架（SIM-CSNs-S），并研究形态学，辛伐他汀释放曲线以及对细胞增殖和分化的影响。对于体内实验，选择SD大鼠的异位成骨和临界尺寸颅骨缺损模型来评估骨再生潜力。所有三种SIM-CSNs-S制剂都具有多孔结构并且表现出持续的辛伐他汀释放。CSNs-S显示出优异的降解和生物相容性特征。4毫克SIM-CSNs-S制剂刺激较高的BMSC ALP活性水平，显着早期胶原蛋白增强，并导致比其他制剂更快的骨再生。

总之，该研究结果显示，SIM-CSNs-S应对骨再生有明显影响。

原始出处：

Xue Y, Wu M, et al., In vitro and in vivo evaluation of chitosan scaffolds combined with simvastatin-loaded nanoparticles for guided bone regeneration. J Mater Sci Mater Med. 2019 Apr 12;30(4):47. doi: 10.1007/s10856-019-6249-3.

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    2019-07-14 zjubiostat

    #纳米粒#

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    2019-04-30 zhangmingxiang

    #辛伐他汀#

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    2019-04-30 lsj630

    #骨再生#

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    2019-04-30 ms920641618706883

    #纳米粒子#

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    2019-04-30 dlwang_26703132

    #壳聚糖#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1772986, encodeId=e6241e7298677, content=<a href='/topic/show?id=89f3e742947' target=_blank style='color:#2F92EE;'>#纳米粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77429, encryptionId=89f3e742947, topicName=纳米粒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8ae38449394, createdName=zjubiostat, createdTime=Sun Jul 14 06:50:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368106, encodeId=41061368106f0, content=<a href='/topic/show?id=f2fd938442c' target=_blank style='color:#2F92EE;'>#辛伐他汀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93844, encryptionId=f2fd938442c, topicName=辛伐他汀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Tue Apr 30 09:50:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472189, encodeId=e9f614e21897b, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Apr 30 09:50:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580661, encodeId=44db15806618f, content=<a href='/topic/show?id=d4c6e7430be' target=_blank style='color:#2F92EE;'>#纳米粒子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77430, encryptionId=d4c6e7430be, topicName=纳米粒子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eedc16636878, createdName=ms920641618706883, createdTime=Tue Apr 30 09:50:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582432, encodeId=83ae1582432b1, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Tue Apr 30 09:50:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609722, encodeId=5e931609e22f9, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Apr 30 09:50:00 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-04-30 ms3994565386320060

    #Med#

    0