Front Microbiol:适度运动可改善改善心脏功能及肠道菌群

2017-10-07 MedSci MedSci原创

通常认为体育锻炼有助于心血管疾病(CVD)的治疗。最近的研究报道显示,运动锻炼可改变肠道微生物群,肠道微生物群的改变可以影响心脏功能。本研究中,研究人员聚焦于心肌梗死(MI)后运动锻炼、肠道微生物群和心脏功能之间的关系。研究人员选取四周龄的C57BL/ 6J小鼠在跑步机上锻炼4周,然后进行左冠状动脉结扎。使用超声心动图评估小鼠的心脏功能。在Illumina HiSeq平台上使用16S rRNA基因

通常认为体育锻炼有助于心血管疾病(CVD)的治疗。最近的研究报道显示,运动锻炼可改变肠道微生物群,肠道微生物群的改变可以影响心脏功能。本研究中,研究人员聚焦于心肌梗死(MI)后运动锻炼、肠道微生物群和心脏功能之间的关系。

研究人员选取四周龄的C57BL/ 6J小鼠在跑步机上锻炼4周,然后进行左冠状动脉结扎。使用超声心动图评估小鼠的心脏功能。在Illumina HiSeq平台上使用16S rRNA基因测序评估运动锻炼后和MI后小鼠肠道微生物的变化。

结果显示,对于心肌梗死后的小鼠,锻炼可抑制心输出量及心博量的降低。此外,锻炼及心肌梗死导致小鼠的肠道菌群发生改变。锻炼可增加Butyricimonas菌及Akk菌的相对丰度。此外,研究人员确定了与运动和心脏功能密切相关的24个谱系(主要来自拟杆菌属、螺杆菌属、紫单胞菌科、疣微菌科、脲原体等)。

这些结果表明,除了改变肠道微生物群之外,运动锻炼在一定程度上改善了小鼠的心脏功能;因此,本研究为使用运动训练来治疗心血管疾病提供新的见解。

原始出处:

Zuheng Liu, Hai-Yue Liu, et al., Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice. Front Microbiol. 2017; 8: 1687. Published online 2017 Sep 1. doi: 10.3389/fmicb.2017.01687

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    2018-05-08 sunylz
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    2018-07-21 xjy02
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    2017-10-08 1e0e5697m83(暂无匿称)

    henhao

    0

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    2017-10-08 1e0e5697m83(暂无匿称)

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