JAHA:动脉僵硬度指数和脉压与心血管疾病及死亡的关系!

2018-01-23 xing.T MedSci原创

由此可见,ASI和PP是心血管疾病和死亡结局的独立预测因子。虽然两者都改善了新发疾病的风险预测,但PP似乎比ASI更具有临床价值。

血管老化导致动脉硬化,并可能在心血管疾病(CVD)的发生发展中发挥作用。通过手指容积描记测量的动脉硬化指数(ASI)和脉压(PP)是2个独立的血管老化指标。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员分析了ASI或PP是否能预测社区人群中新发病的心血管病和死亡个体。

研究人员分析了169613名英国生物库的参与者(平均年龄为56.8岁;男性占45.8%),这些患者进行了ASI测量和计算了PP。ASI的平均数±SD为9.30×3.1m/s,PP的平均数±SD为50.98±13.2mmHg。针对CVD中位随访时间为2.8年(四分位距为1.4-4),18190名受试者发生了CVD,其中1587名受试者为心肌梗死(MI)患者,4326名为冠心病患者,1192名为心力衰竭患者和1319名卒中患者。

针对死亡的平均随访长达6.1年(四分位距为5.8-6.3),3678名参与者死亡,其中1180名死于CVD。较高的ASI与总体CVD(校正后的风险比为1.27;95%可信区间[CI]为1.25-1.28)、心肌梗死(1.38;95%CI为1.32-1.44)、冠心病(1.31;95%CI为1.27-1.34)、心衰(1.31;95%CI为1.24-1.37)风险增加相关。ASI还可预测死亡(全因、CVD和其他)。较高的PP与整体CVD(1.57,95% CI为1.55-1.59)、心肌梗死(1.48,95%CI为1.42-1.54)、冠心病(1.47,95%CI为1.43-1.50)、心脏衰竭(1.47,95%CI为1.40-1.55)和CVD死亡(1.47,95%CI为1.40-1.55)风险增加相关。PP可以使非实验室为基础的Framingham风险评分CVD风险重分类改善5.4%,ASI可以改善2.3%。

由此可见,ASI和PP是心血管疾病和死亡结局的独立预测因子。虽然两者都改善了新发疾病的风险预测,但PP似乎比ASI更具有临床价值。

原始出处:

M. Abdullah Said,et al. Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality.JAHA.2018. https://doi.org/10.1161/JAHA.117.007621

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    2018-02-02 lofter

    学习了感谢分享

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    2018-01-24 zhaohui6731
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level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 23 08:52:16 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281193, encodeId=7f9d2811937b, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Jan 23 08:13:27 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281188, encodeId=0f3528118887, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jan 23 08:11:59 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 邓启付

    动脉僵硬度指数越高心血管疾病风险越大.

    0

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level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Jan 23 08:52:16 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281193, encodeId=7f9d2811937b, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Jan 23 08:13:27 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281188, encodeId=0f3528118887, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jan 23 08:11:59 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 明月清辉

    谢谢分享.学习了

    0

  8. 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    2018-01-23 神功盖世

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jan 23 08:11:59 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jan 23 08:11:59 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 龙胆草

    学习谢谢分享

    0