Obstet Gynecol:未足月诊断子痫前期其死胎风险更大

2015-03-09 Mechront MedSci原创

<span style="font-size:10.5pt;mso-bidi-font-size:11.0pt; font-family:宋体;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor-latin; mso-fareast-theme-font:minor-fareast;mso-hansi-fon

子痫前期是常见的妊娠相关疾病,以高血压、蛋白尿为主要表现,与死胎风险的增高密切相关。但是目前临床上,对于足月或未足月发生的子痫前期,二者之一谁对母胎危害性更大,尚无定论,因此,Quaker E进行了一项基于人群的队列研究,以探究子痫前期孕周特异性的死胎风险。

该研究纳入了挪威地区1999-2008年554,333名宫内单活胎的孕妇,其中21,020名(3.8%)孕妇为子痫前期,余下533,313名(96.2%)孕妇没有子痫前期。



对于研究对象整体而言,每1,000名孕妇中有3.6名是死胎,对于子痫前期群体而言,该数据为5.2/1,000名,其相对危险度RR=1.45,95% CI 1.20-1.76。但是在较早孕周,子痫前期组的死胎数据明显高于不伴子痫前期的孕妇。孕26周,子痫前期组每1,000名孕妇中有11.6名是死胎,而非子痫前期组该数据仅为0.1/1,000,RR=86,95% CI 46-142。研究结果显示,随着子痫前期诊断孕周的增加,其死胎风险呈下降趋势,但是虽然如此,在孕34周,子痫前期组的死胎风险仍高于对照组7倍,该数据不可忽视。

该研究结果表明,死胎风险与子痫前期诊断孕周(即出现子痫前期症状的孕周)密切相关,孕周越小,风险越大。临床上,孕妇一旦诊断子痫前期,需要根据其诊断孕周,评估相应的母胎风险。

原始出处:

Quaker E. Harmon,et al. Risk of Fetal Death With Preeclampsia. Obstet Gynecol 2015;125:628–35

本文系Medsci原创编译整理!转载需要先获得授权,并附原文链接。谢谢!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2011172, encodeId=2c9020111e2f2, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Wed Jul 08 23:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043834, encodeId=958220438348c, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jun 27 09:31:00 CST 2015, time=2015-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366530, encodeId=f06b136653081, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508410, encodeId=a5431508410c8, content=<a href='/topic/show?id=0bc66341438' target=_blank style='color:#2F92EE;'>#死胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63414, encryptionId=0bc66341438, topicName=死胎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd2a9955567, createdName=bsmagic9135, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18058, encodeId=0260180584f, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=183.227.44.**, createdTime=Mon Mar 09 23:50:00 CST 2015, time=2015-03-09, status=1, ipAttribution=)]
    2015-07-08 yhy100200
  2. [GetPortalCommentsPageByObjectIdResponse(id=2011172, encodeId=2c9020111e2f2, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Wed Jul 08 23:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043834, encodeId=958220438348c, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jun 27 09:31:00 CST 2015, time=2015-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366530, encodeId=f06b136653081, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508410, encodeId=a5431508410c8, content=<a href='/topic/show?id=0bc66341438' target=_blank style='color:#2F92EE;'>#死胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63414, encryptionId=0bc66341438, topicName=死胎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd2a9955567, createdName=bsmagic9135, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18058, encodeId=0260180584f, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=183.227.44.**, createdTime=Mon Mar 09 23:50:00 CST 2015, time=2015-03-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2011172, encodeId=2c9020111e2f2, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Wed Jul 08 23:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043834, encodeId=958220438348c, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jun 27 09:31:00 CST 2015, time=2015-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366530, encodeId=f06b136653081, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508410, encodeId=a5431508410c8, content=<a href='/topic/show?id=0bc66341438' target=_blank style='color:#2F92EE;'>#死胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63414, encryptionId=0bc66341438, topicName=死胎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd2a9955567, createdName=bsmagic9135, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18058, encodeId=0260180584f, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=183.227.44.**, createdTime=Mon Mar 09 23:50:00 CST 2015, time=2015-03-09, status=1, ipAttribution=)]
    2015-03-11 yahu
  4. [GetPortalCommentsPageByObjectIdResponse(id=2011172, encodeId=2c9020111e2f2, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Wed Jul 08 23:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043834, encodeId=958220438348c, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jun 27 09:31:00 CST 2015, time=2015-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366530, encodeId=f06b136653081, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508410, encodeId=a5431508410c8, content=<a href='/topic/show?id=0bc66341438' target=_blank style='color:#2F92EE;'>#死胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63414, encryptionId=0bc66341438, topicName=死胎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd2a9955567, createdName=bsmagic9135, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18058, encodeId=0260180584f, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=183.227.44.**, createdTime=Mon Mar 09 23:50:00 CST 2015, time=2015-03-09, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2011172, encodeId=2c9020111e2f2, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Wed Jul 08 23:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043834, encodeId=958220438348c, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jun 27 09:31:00 CST 2015, time=2015-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366530, encodeId=f06b136653081, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508410, encodeId=a5431508410c8, content=<a href='/topic/show?id=0bc66341438' target=_blank style='color:#2F92EE;'>#死胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63414, encryptionId=0bc66341438, topicName=死胎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd2a9955567, createdName=bsmagic9135, createdTime=Wed Mar 11 13:31:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18058, encodeId=0260180584f, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=183.227.44.**, createdTime=Mon Mar 09 23:50:00 CST 2015, time=2015-03-09, status=1, ipAttribution=)]
    2015-03-09 183.227.44.**

    ?

    0

相关资讯

Hypertension:子痫前期女性的瘦素浓度较高

瘦素(Leptin,LP)是一种由脂肪细胞分泌的激素,在血管形成和再生方面也起着重要的作用。丹麦学者对瘦素和子痫前期的关联性进行了巢式病例对照研究,结果表明,与血压正常的受试者相比,子痫前期女性的瘦素浓度较高,它可能介导了体质指数(BMI)和子痫前期之间的关系。相关论文12月15日在线发表于《高血压》(HYPERTENSION)杂志。 研究纳入了430例子痫前期初产妇和316例血