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J Periodontol：局部应用替鲁膦酸对糖尿病大鼠实验性牙周炎的影响

2017-09-25 lishiting MedSci原创

TIL牙周炎糖尿病
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替鲁膦酸(TIL)具有抗吸收和抗炎特性，并且在牙周炎-糖尿病(DM)联系中是否发挥作用从未进行过研究。这篇研究的目的是对链脲霉素诱导DM的大鼠局部施以TIL，观察和评估TIL对大鼠实验性牙周炎(EP)的影响。

替鲁膦酸(TIL)具有抗吸收和抗炎特性，并且在牙周炎-糖尿病(DM)联系中是否发挥作用从未进行过研究。这篇研究的目的是对链脲霉素诱导DM的大鼠局部施以TIL，观察和评估TIL对大鼠实验性牙周炎(EP)的影响。

研究将32只实验动物(Rattus norvegicus， albinus， Wistar)分为4组：DM/C (对照组)， DM/EP， DM/EP/TIL1和DM/EP/TIL3。在EP组，将一条结扎线放置于大鼠下颌磨牙(MM)周围。在DM/EP/TIL1和DM/EP/TIL3组，TIL溶液(1和3 mg/kg)分别在10天内、每隔一天注射至MM牙龈组织内，直至实验动物安乐死。随后通过micro-CT、组织形态测定法、免疫组织化学(TRAP， RANKL， OPG， cleaved caspase 3)和qRT-PCR (IL-1？， VEGF)对牙周组织进行分析评估。

Micro-CT分析显示，DM/EP/TIL1和DM/EP/TIL3组牙槽骨吸收减少(p<0.05)。DM/EP/TIL3组的附着丧失降低(p<0.05)。TIL组的TRAP阳性多核细胞数量减少(p<0.05)。DM/EP/TIL3组的RANKL免疫标记较低(p<0.05)。另外，施以TIL治疗降低了IL-1？的基因表达，并且DM/EP/TIL3组的VEGF表达明显升高(p<0.05)。

结论：局部施以TIL对糖尿病大鼠因EP造成的组织破坏起到了促进保护的作用，并且TIL剂量在3 mg/kg时可以发挥最好的抗吸收和抗炎症效果。

原始出处：

Nunes NLT， Messora MR， et al. Effects of Local Administration of Tiludronic Acid on Experimental Periodontitis in Diabetic Rats. J Periodontol. 2017 Sep 15：1-19. doi： 10.1902/jop.2017.170228.

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    2018-01-11 feather89

    #PE#

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    2017-12-31 lujian

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    #牙周#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1726768, encodeId=b8f91e2676878, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jan 11 16:33:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040702, encodeId=37032040e02c1, content=<a href='/topic/show?id=5887461103d' target=_blank style='color:#2F92EE;'>#实验性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46110, encryptionId=5887461103d, topicName=实验性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Sun Dec 31 06:33:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079566, encodeId=b18620e956667, content=<a href='/topic/show?id=21564611139' target=_blank style='color:#2F92EE;'>#实验性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46111, encryptionId=21564611139, topicName=实验性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ced3193, createdName=freve, createdTime=Thu Dec 14 06:33:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405757, encodeId=93a11405e5788, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Wed Sep 27 10:33:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450651, encodeId=f815145065195, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Sep 27 10:33:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247677, encodeId=d72724e67798, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Sep 25 22:44:25 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-25 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

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