Diabetes Care:胎儿性别可能会潜在影响孕妇葡萄糖代谢

2015-05-07 MedSci MedSci原创

通过对围产期数据库进行回顾性分析发现了一个有趣的现象:当孕妇怀有一个男性胎儿时其妊娠糖期尿病(GDM)风险可能会增加,但是两者之间是否真的存在某种联系尚不明确。因此Retnakaran R等人进行了一项研究,评估胎儿性别和孕妇葡萄糖代谢之间的关系,该队列包括了从妊娠期糖耐量正常孕妇,轻度异常孕妇和GDM孕妇。共计1,074名孕妇在平均29.5周孕行OGTT试验。其中534名孕妇胎儿为女性,余下54

通过对围产期数据库进行回顾性分析发现了一个有趣的现象:当孕妇怀有一个男性胎儿时其妊娠糖期尿病(GDM)风险可能会增加,但是两者之间是否真的存在某种联系尚不明确。因此Retnakaran R等人进行了一项研究,评估胎儿性别和孕妇葡萄糖代谢之间的关系,该队列包括了从妊娠期糖耐量正常孕妇,轻度异常孕妇和GDM孕妇。

共计1,074名孕妇在平均29.5周孕行OGTT试验。其中534名孕妇胎儿为女性,余下540名孕妇胎儿为男性。研究者比较了两者GDM的流行情况,病理生理的因素(β细胞功能和胰岛素抵抗),以及GDM临床危险因素。

研究结果发现,相比女性胎儿孕妇,怀有男性胎儿的孕妇其β细胞调整功能更低(9.4 vs. 10.5, P = 0.007),OGTT血糖结果更高30分钟(P = 0.025),1小时(P = 0.004),2小时(P = 0.02)。此外,研究者发现怀有男性胎儿的孕妇有更高的可能性发展成为GDM(OR 1.39 95% CI 1.01-1.90)。事实上,孕妇年龄> 35年和非白人种族分别为男性胎儿导致GDM相对风险增加提供了47%和51%的可能。

研究结果表明,男性胎儿会导致孕妇有更差的β细胞功能、更高的餐后血糖、同时妊娠期糖尿病的风险增加。因此,胎儿性别可能会潜在影响孕妇葡萄糖代谢。

原始出处:

Retnakaran R, Kramer CK, Ye C, et al. Fetal sex and maternal risk of gestational diabetes mellitus: the impact of having a boy. Diabetes Care. 2015. 38(5): 844-51.

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    2015-05-09 zz70
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    2015-05-07 huaxipanxing

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Li LJ等人近期进行了一项有趣的研究,探究孕中期母体视网膜微脉管系统情况与胎儿宫内生长和出生时大小的关系。该研究共纳入732名单胎妊娠、孕早期、18-46岁的孕妇,在26-28周孕时对母体行视网膜眼底照相,同时行胎儿B超检查记录头围等生长数据。接着在32-34周孕对胎儿行B超检查再次记录生长数据。当胎儿出生时对其测量生长发育参数。用计算机软件对视网膜眼底照相进行处理分析,得到视网膜微脉管系统相关