Lancet Infect Dis:血清学分析在新加坡新冠肺炎患者流行病学调查中的应用

2020-04-22 MedSci原创 MedSci原创

研究认为,新冠肺炎血清学分析的发展和应用有助于建立患者之间的流行病学关联,特别是对于恢复期病例或可能被其他监测方法遗漏的较轻症状患者具有极高的敏感性

阐明疾病传播链和确定2019年冠状病毒疾病(COVID-19)感染的来源是遏制疾病的关键。近日研究人员开展流行病学调查,使用严重急性呼吸综合征冠状病毒2(SARS-COV-2)血清学检测,建立了三组COVID-19患者之间的联系。

在新加坡,研究人员对所有COVID-19病例进行了积极的病例调查和接触者追踪。用RT-PCR检测证实疾病诊断。当流行病学资料显示患者可能是疾病传播的节点,但已经从疾病中恢复时,采用SARS-CoV-2IgG血清学检测来确定过去的感染。

在新加坡发现了三组COVID-19聚集疫情,包括28例本地传播的病例,这些病例来自两个教堂(A教堂和B教堂)和一个家庭聚会。A教堂和B教堂的患者由A教堂(A2)的一名个人联系在一起,他们在2020年1月25日参加的家庭聚会上将SARS-CoV-2感染传染给了B教堂(F1)的主要病例。所有病例均经RT-PCR检测证实为活动性疾病,但A2除外,A2在检测时已痊愈,检测呈阴性。

研究认为,新冠肺炎血清学分析的发展和应用有助于建立患者之间的流行病学关联,特别是对于恢复期病例或可能被其他监测方法遗漏的较轻症状患者具有极高的敏感性。

原始出处:

Sarah Ee Fang Yong et al. Connecting clusters of COVID-19: an epidemiological and serological investigation.Lancet Infect Dis. April 21,2020.

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    2020-05-07 howi
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    2020-04-22 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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