Neurology:颈动脉夹层动脉瘤预后如何?

2017-01-15 xing.T MedSci原创

CADISS研究结果提供的证据表明,夹层动脉瘤可能有良性预后,因此应考虑给予积极治疗。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在明确夹层动脉瘤的自然疾病史,以及夹层动脉瘤是否与复发性脑卒中增加的风险有关;另外进一步明确抗血栓药物类型(抗血小板药与抗凝血剂)是否能够改善夹层动脉瘤的持续状态或进展。

研究人员从颈动脉夹层的脑卒中研究(CADISS研究)中选取了264例颅外颈动脉夹层患者,CADISS研究是一项比较抗血小板与抗凝治疗的多中心前瞻性研究。研究人员采用Logistic回归分析来估计年龄和性别调整的比值比,并且进行了对评估夹层动脉瘤的自然疾病史和非手术治疗的颅外颈动脉夹层伴有夹层动脉瘤的患者脑卒中风险的已发表研究进行了系统回顾。

在CADISS研究中,在研究之初264例参与者中有24名为夹层动脉瘤患者。在影像学随访了3个月的248例参与者中有36例夹层动脉瘤患者,其中12例为研究之初24例夹层动脉瘤患者持续演变而来,另有24例为新发夹层动脉瘤患者。在治疗分配没有任何关联(抗血小板和抗凝药物)是否大基线持续跟进或是否有新的大发展。在12个月的随访期间,在48例夹层动脉瘤患者中有1名患者发生脑卒中,而在216例无夹层动脉瘤的患者中有7名患者发生脑卒中(调整了年龄和性别的比值比为0.84;95%可信区间为0.10-0.73;P=0.88)。在发表的研究中,以回顾性研究为主,显示了类似的低卒中风险,但是没有证据表明夹层动脉瘤患者卒中发生率增加。


由此可见,CADISS研究结果提供的证据表明,夹层动脉瘤可能有良性预后,因此应考虑给予积极治疗。

原始出处:

Susanna C. Larsson, et al. Prognosis of carotid dissecting aneurysms. Neurology.January 13, 2017. 

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    2017-04-12 yinhl1978
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    2017-01-16 天涯183

    恩,很重要的问题

    0

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    2017-01-15 知难而进

    学习了!!!!!!!!

    0

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    2017-01-15 inter158

    夹层动脉瘤可能有良性预后,因此应考虑给予积极治疗。

    0

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    2017-01-15 thlabcde

    好东西学习了!

    0