治疗原发性高血压全新动态,你可能不知道的?

2017-07-12 MedSci MedSci原创

原发性高血压的认知高血压是常见危害人类健康的心血管疾病,其中绝大多数患者为原发性高血压。原发性高血压是基于目前的医学发展水平和检查手段,不能发现导致血压升高的确切病因。2005年美国高血压学会(ASH)提出,高血压是一个由许多病因引起的处于不断进展状态的心血管综合征,可导致心脏、血管功能与结构的改变和肾脏损伤。肾动脉与高血压的关联肾脏既是交感神经兴奋的对象又是兴奋的促进者,肾交感神经的激活对高血压

原发性高血压的认知
高血压是常见危害人类健康的心血管疾病,其中绝大多数患者为原发性高血压。原发性高血压是基于目前的医学发展水平和检查手段,不能发现导致血压升高的确切病因。2005年美国高血压学会(ASH)提出,高血压是一个由许多病因引起的处于不断进展状态的心血管综合征,可导致心脏、血管功能与结构的改变和肾脏损伤。


肾动脉与高血压的关联
肾脏既是交感神经兴奋的对象又是兴奋的促进者,肾交感神经的激活对高血压的发生及发展具有重要作用,其主要机制为影响。肾传入神经主要发源于肾盂管壁,具有调节交感信号传出的功能。肾传出神经激活,引起肾血管收缩,肾血流量和肾小球滤过率降低而导致肾脏缺血性损伤,促进肾素分泌,激活RAAS,引发相应生物学效应。肾脏的缺血缺氧、肾脏损伤等因素可刺激肾脏传入神经,经下丘脑交感神经中枢等器官和系统的交感传出信号增强,进而引起血压升高。现已证实β-受体阻滞剂、血管紧张素转化酶抑制剂、血管紧张素受体拮抗剂等交感神经与RAAS阻滞剂可以有效降低血压、减少心脑血管事件。肾动脉消融去神经技术作为交感神经和RAAS活性的非药物阻滞技术被成功应用于顽固性高血压的临床治疗。

临床试验招募啦!
全国多家大型医院正在开展一项肾动脉消融组治疗原发性高血压的临床研究,如您是原发性高血压患者,欢迎您的随时参与本次临床研究。本次临床试验和实施方案,已经在中国国家食品药品监督管理总局登记注册(注册号:MS201700012)。按照本次临床实施方案规定,入选的患者将 1:1 比例随机分配至肾动脉消融组(消融组)和单纯肾动脉造影组(假手术组)。

新药介绍
肾动脉去神经治疗源于20世纪40、50年代的胸腰部内脏神经切除术。胸腰部内脏神经切除术可以有效降低恶性高血压患者的血压水平、增强血压控制率。但胸腰部内脏神经切除技术的器官选择性较差,不能达到内脏神经的器官或者局部选择性切除,患者病痛较大和并发症较高。2009年世界上首次导管肾动脉消融去神经技术被成功应用于顽固性高血压治疗的临床研究中。近年,世界范围内多个国家和地区的心脏中心验证了经导管肾动脉消融技术对于顽固性高血压有显著的降压效果,无相关不良事件发生同时可以显著改善患者生活质量。

参加条件
1. 年龄18~65岁的男性,女性未在妊娠、哺乳期,且一年内无生育计划;
2. 原发性高血压患者;高血压病程6个月以上;
3. 血压测量诊室收缩压150~180mmHg;且在未用β-受体阻滞剂情况下静息心率≥70bpm;服用β-受体阻滞剂者不考虑心率指标。
4. 动态血压测量24小时平均收缩压≥130mmHg、或白天≥135mmHg、或夜间≥120mmHg;
5. 六个月内有抗高血压用药史,血压仍不能控制;并在入组前进行至少28天的标准化用药(至少两种药物),且服药依从性≥80%,诊室收缩压仍150~180mmHg;
医生将根据您的具体情况,进一步确认是否符合条件。

研究中心列表(就近原则)
北京大学人民医院
北京大学第三医院
北京大学第一医院
天津市第一中心医院
白求恩国际和平医院
河北省人民医院
上海中山医院
上海仁济医院
南京市第一医院
江苏省人民医院
武汉大学人民医院
重庆医科大学附属二院
华西医院

点击下方图片即可报名加入原发性高血压临床试验活动

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    2017-08-08 yese
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    2017-07-17 lou.minghong

    学习了谢谢分享!

    0

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    2017-07-13 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

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    2017-07-12 1e172a6bm25(暂无匿称)

    高血压危害大

    0

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    2017-07-12 lyh994

    技术又进步了

    0