Lasers Surg Med:辅助光动力疗法治疗一般侵袭性牙周炎的疗效分析

2020-06-17 MedSci原创 MedSci原创

广泛性侵袭性牙周炎(GAgP)是一种独特的牙周疾病,其特征是在年轻个体中发生的附着力和牙槽骨快速丧失。光动力疗法(PDT)作为牙周炎患者非手术性牙周治疗(NPT)的辅助方法被引入牙周病学。在该试验中,

广泛性侵袭性牙周炎(GAgP)是一种独特的牙周疾病,其特征是在年轻个体中发生的附着力和牙槽骨快速丧失。光动力疗法(PDT)作为牙周炎患者非手术性牙周治疗(NPT)的辅助方法被引入牙周病学。在该试验中,目的是评估GAgP患者中辅助性PDT对NPT的临床和微生物学作用。

 

在这项前瞻性对照临床研究中,纳入了24名具有GAgP的系统健康,非吸烟受试者。将受试者随机分为仅接受NPT治疗的对照组(n = 12)或接受NPT和PDT治疗的测试组(n = 12)。在基线和第63天记录斑块指数,沟出血指数(SBI),探查深度(PD),相对附着水平,牙龈退缩和牙齿活动度。两次均从PD≥5 mm的部位获得微生物样本期间,通过micro-IDent®测试评估了放线杆菌,牙龈卟啉单胞菌,中间型普氏杆菌,连翘坦氏菌和密螺旋体。

 

结果显示,治疗后两组的临床和微生物参数均显著下降(P <0.01)。两组之间的比较显示,在第63天,仅试验组的全口SBI评分显着低于对照组(P <0.05)。尽管试验组牙周病原菌的减少量大于对照组,但各组之间无显着差异(P> 0.05)。

 

在本研究的范围内,可以得出结论,在治疗GAgP时,除SBI以外,使用PDT作为NPT的辅助剂不会对研究的临床和微生物学参数产生任何有益影响。尽管如此,SBI评分的统计学显着性差异表明,PDT可能对减少牙龈出血具有其他作用。

 

原始出处:

 

Tugce Borekci, Suleyman Emre Meseli, et al., Efficacy of Adjunctive Photodynamic Therapy in the Treatment of Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial. Lasers Surg Med. 2019 Feb;51(2):167-175. doi: 10.1002/lsm.23010.  

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    2020-06-17 内科新手

    谢谢梅斯提供这么好的信息,学到很多

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    2020-12-16 anminleiryan
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    2020-06-19 sunyl07
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氧化应激已被认为是糖尿病慢性牙周炎(CPDM)的一个重要致病因素,而核因子相关因子2(Nrf2)在细胞防御氧化应激中发挥着重要作用。有研究提出黄芩素(BCI)在氧化应激相关疾病中的潜在治疗特性。