J Hypertens:2型糖尿病患者的长期血压变异性与慢性肾病之间的关系

2019-01-08 xing.T MedSci原创

由此可见,长期血压变异性增加可预测T2D合并高血压患者的CKD。

长期访视间SBP变异性(VVV)已被证实可预测慢性肾病(CKD)患者的脑血管事件和终末期肾病。目前尚不确定SBP的VVV是否也是糖尿病患者CKD发展的预测指标。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员旨在评估SBP的VVV在2型糖尿病(T2D)患者和现实生活中高血压患者CKD发生的作用。

该研究分析了30851例估计的肾小球滤过率(eGFR)正常的T2D合并高血压患者的临床记录,并定期随访4年。SBP变异性通过三个指标来衡量:变异系数、平均SBP的SD和每个个体连续测量值的平均绝对差异。CKD定义为eGFR小于60和/或eGFR从基线降低至少30%。

在4年的随访中,9.7%的参与者eGFR小于60%,4.5%的参与者eGFR从基线降低至少30%。一些临床特征(年龄较大、男性、SBP、DBP、白蛋白尿、糖化血红蛋白、胰岛素治疗)与个体的SBP变异性有关。VVV为较高五分位数的患者发生CKD两种组分的风险增加[调整后的比值比(OR)分别为1.21,P<0.001和1.32,P<0.001)。对于CKD发病率,SBP变异系数处于第2至第5个五分位数的多变量调整ORs逐渐增加(OR为1.04,P=0.601,OR为1.05,P=0.520,OR为1.21,P<0.017和OR为1.42,P<0.001与第1个五分位数相比)。

由此可见,长期血压变异性增加可预测T2D合并高血压患者的CKD。

原始出处:

Viazzi, Francesca.et al.Long-term blood pressure variability and development of chronic kidney disease in type 2 diabetes. Journal of Hypertension. 2019. https://journals.lww.com/jhypertension/Abstract/publishahead/Long_term_blood_pressure_variability_and.97289.aspx

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    2019-01-09 心介

    #血压变异性#相信未来5年是热点,不仅关心血压高与低,还要关注血压变异性才可以

    0

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    2019-01-09 misszhang

    谢谢MedSci提供最新的资讯

    0

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近日,国际杂志 《Diabetic Med》上在线发表一项关于巨细胞病毒血清阳性与2型糖尿病之间的关联的国家健康与营养调查研究。评估来自国家健康和营养调查的6664名参与者中巨细胞病毒与2型糖尿病之间的关联。 研究人员使用了1999年至2004年参加国家健康和营养调查的20-49岁成人的现有数据。使用巨细胞病毒特异性免疫球蛋白G抗体测定巨细胞病毒状态。通过自我报告或≥7mmol/l的血浆空

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