Int J Vitam Nutr Res:补充ω-3脂肪酸和维生素E能显著降低机体的炎症反应

2020-11-09 MedSci原创 MedSci原创

有几项研究调查了ω-3脂肪酸和维生素E对氧化应激和炎症的影响,但其结果并不一致。本荟萃分析旨在阐明ω-3脂肪酸和维生素E共同补充对氧化应激和炎症的影响。

有几项研究调查了ω-3脂肪酸和维生素E对氧化应激和炎症的影响,但其结果并不一致。本荟萃分析旨在阐明ω-3脂肪酸和维生素E共同补充对氧化应激和炎症的影响。
研究人员搜索了PubMed、ISI、Scopus和Google Scholar数据库中索引的相关文章的标题、摘要和关键词,直至2018年12月,以确定符合条件的RCT研究。使用随机效应模型来估计补充ω-3脂肪酸和维生素E对氧化应激和炎症的集合效应。
 
结果,本荟萃分析纳入了7项RCT,包括504名参与者。分析发现,与对照组相比,补充ω-3脂肪酸和维生素E可降低hs-CRP的浓度(加权平均差异(WMD)=-2.15 mg/L;95% CI:-3.40,-0.91 mg/L;P <0.001),增加了总抗氧化能力(TAC)(WMD = 92.87 mmol/L;95% CI:31.97,153.77 mmol/L;P = 0.03),以及一氧化氮的水平(NO)(WMD:6.95 μmol/L;95% CI:3.86,10.04,P <0.001)。Omega-3脂肪酸和维生素E对丙二醛(MDA)(WMD:1.54 mmol/L;95% CI:-1.29,4.36;P = 0.196)和谷胱甘肽(GSH)(WMD:20.87 mmol/L;95% CI:-20.04,61.6,P = 0.31)的水平无显著影响。
 
综上所述,本荟萃分析发现,补充ω-3脂肪酸和维生素E能显著降低hs-CRP,增加NO和TAC,尽管它对MDA和GSH没有显著影响。
 
原始出处:
 
Seyedeh Parisa Moosavian, Arman Arab, et al., The effect of omega-3 and vitamin E on oxidative stress and inflammation: Systematic review and meta-analysis of randomized controlled trials. Int J Vitam Nutr Res. 2020 Oct;90(5-6):553-563. doi: 10.1024/0300-9831/a000599.

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    2020-12-28 ms6000000854809298

    学习了

    0

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    2020-11-11 ms5000000518166734

    学习了!很好

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    2020-11-10 ms4000000062793346

    学习学习

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    2020-11-09 ms7000001395190706

    学习了

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