Hepatology:预测2030年全世界30个国家原发性肝细胞癌负担

2017-09-04 MedSci MedSci原创

原发性肝细胞癌(PLC)是世界上第六大癌症,第二大癌症死亡原因。预测未来原发性肝癌的负担能够提高公民对癌症控制的认知。

原发性肝细胞癌(PLC)是世界上第六大癌症,第二大癌症死亡原因。预测未来原发性肝癌的负担能够提高公民对癌症控制的认知。

我们预测了2030年前后30个国家未来的PLC的负担。1993-2007年,在30个国家收集PLC病例。采用年龄-时期-队列模型(NORDPRED)预测2030年前后30个国家新发生PLC的患者数目。每10万人年的年龄标准化发病率是按国家和性别计算的。PLC新增病例和PLC发病率在男女中都有预测。挪威男性PLC发病率增幅最大(2.9%每年)、美国白人男性PLC发病率为2.6% /每年、加拿大男性PLC发病率为2.4% /每年;美国黑人女性、瑞士女性、德国女性的PLC发病率分别为4.0% /每年、3.4% /每年、3.0% /每年。预测中国、日本、新加坡、欧洲部分国家(例如爱沙尼亚、捷克共和国、斯洛伐克)PLC发病率将下降。与2005年相比,每年新增病例将增加35%。PLC负担增加反映了PLC发病率增加(潜在危险因素的流行)与人口结构的变化。预计到2030年,日本将是世界上唯一的一个年净病例和年增长率下降的国家。

研究表明,到2030年,在30个国家中,PLC发病率预计将增加。这些数据可以做为通过接种和治疗促使HBV和HCV感染长期下降的基线数据;染而,随着肥胖人群的增加及其代谢并发症的增加可能会抵消这些收益的PLC,这是一个值得关注的问题。

原始出处:

Valery PC, Laversanne M, Clark PJ, et al. Projections of primary liver cancer to 2030 in 30 countries worldwide. Hepatology, 2017, 2017 Aug 31. doi: 10.1002/hep.29498.

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    2017-11-06 xjy02
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    2017-09-06 gwc384

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