Epilepsia:激光消融治疗内侧颞叶癫痫

2017-06-16 MedSci MedSci原创

探讨如何设计消融部位和激光轨迹以最大程度控制癫痫发作,并最大限度地减少内侧颞叶癫痫(mTLE)患者接受激光间质热疗(LiTT)的神经认知缺陷的风险。

目的:探讨如何设计消融部位和激光轨迹以最大程度控制癫痫发作,并最大限度地减少内侧颞叶癫痫(mTLE)患者接受激光间质热疗(LiTT)的神经认知缺陷的风险。

方法:从前瞻性的数据库中回顾了临床和影像学资料在迈阿密医院大学接受麻醉药治疗的患者接受了mTLE治疗。在所有患者中进行术前和术后评估,包括对比增强磁共振成像(MRI)和神经心理测试。激光轨迹和消融体积是通过手动追踪时空结构和根据7T MRI数据的消融灶融合到共同的参考系统中后,进行计算得出。

结果:在23例至少1年随访的患者中,15例(65%)患者术后癫痫不再发作。内侧颞叶海马结构残留与持续性不稳定性癫痫发作显着相关(p = 0.01)。通过海马的侧向轨迹与癫痫发作结果恶化相关(p = 0.08)。基线和术后神经认知测试的比较显示改善和恶化的部位,与消融体积或轨迹无关。

结论:在1年的随访中,LiTT似乎是治疗mTLE的安全有效的工具,尽管需要较长的随访期来确认这些意见。今后需更好地了解消融体积和位置的影响,并对这项技术进行改进,以改善癫痫控制率和认知。

原文出处:

Jermakowicz WJ, Kanner AM, Sur S,et al. Laser thermal ablation for mesiotemporal epilepsy: Analysis of ablation volumes and trajectories. Epilepsia.28 Feb 2017, 58(5):801-810. DOI: 10.1111/epi.13715.


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    2018-04-22 lq1767
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    2017-06-17 oliver169
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    2017-06-17 meiliwuxian

    不错

    0

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