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CDKL5 deficiency in forebrain glutamatergic neurons results in recurrent spontaneous seizures

期刊: EPILEPSIA, 2021; 62 (2)

Objective Mutations of the cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders characterized by intractable epilepsy......

Automatic detection of interictal ripples on scalp EEG to evaluate the effect and prognosis of ACTH therapy in patients with infantile spasms

期刊: EPILEPSIA, 2021; 62 (9)

Objective We aimed to explore the feasibility of using scalp-recorded high-frequency oscillations (HFOs) to evaluate the efficacy and prognosis of adr......

Educational attainment protects against epilepsy independent of cognitive function: A Mendelian randomization study

期刊: EPILEPSIA, 2021; 62 (6)

Objective Observational studies have suggested that increased levels of education and cognition are associated with a reduced risk of epilepsy. Howeve......

Defining Dravet syndrome: An essential pre-requisite for precision medicine trials

期刊: EPILEPSIA, 2021; 62 (9)

Objective The classical description of Dravet syndrome, the prototypic developmental and epileptic encephalopathy, is of a normal 6-month-old infant p......

The molecular and phenotypic spectrum of CLCN4-related epilepsy

期刊: EPILEPSIA, 2021; 62 (6)

Objective This study was undertaken to expand the phenotypic and genetic spectrum of CLCN4-related epilepsy and to investigate genotype-phenotype corr......

CSNK2B: A broad spectrum of neurodevelopmental disability and epilepsy severity

期刊: EPILEPSIA, 2021; 62 (7)

CSNK2B has recently been implicated as a disease gene for neurodevelopmental disability (NDD) and epilepsy. Information about developmental outcomes h......

Neural recruitment by ephaptic coupling in epilepsy

期刊: EPILEPSIA, 2021; 62 (7)

Objective One of the challenges in treating patients with drug-resistant epilepsy is that the mechanisms of seizures are unknown. Most current interve......

Defining the latent period of epileptogenesis and epileptogenic zone in a focal cortical dysplasia type II (FCDII) rat model

期刊: EPILEPSIA, ; ()

Objectives Focal cortical dysplasia type II (FCDII) is one of the most common underlying pathologies in patients with drug-resistant epilepsy. However......

The road to a World Health Organization global action plan on epilepsy and other neurological disorders

期刊: EPILEPSIA, ; ()

The World Health Organization (WHO) has recognized epilepsy as a public health imperative due to its occurrence at all ages in all regions of the worl......

Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool

期刊: EPILEPSIA, ; ()

Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug-res......

Topographical reorganization of brain functional connectivity during an early period of epileptogenesis

期刊: EPILEPSIA, ; ()

Objective: The current study aims to investigate functional brain network representations during the early period of epileptogenesis. Methods: Eightee......

LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on gamma-aminobutyric acid type A receptors

期刊: EPILEPSIA, 2021; 62 (1)

Objective: LMR-101 is a bisphenol derivative of propofol, a short-acting general anesthetic, which is also used to manage status epilepticus (SE). We ......

Automated seizure detection using wearable devices: A clinical practice guideline of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology

期刊: EPILEPSIA, 2021; 62 (3)

The objective of this clinical practice guideline (CPG) is to provide recommendations for healthcare personnel working with patients with epilepsy on ......

Shared hippocampal abnormalities in sporadic temporal lobe epilepsy patients and their siblings

期刊: EPILEPSIA, 2020; 61 (4)

Objective To examine the shared familial contribution to hippocampal and extrahippocampal morphological abnormalities in patients with sporadic tempor......

Somatic variants in new candidate genes identified in focal cortical dysplasia type II

期刊: EPILEPSIA, 2020; 61 (4)

Objective Focal cortical dysplasia type II (FCDII) is a malformation of cortex development commonly found in children with drug-resistant epilepsy. FC......

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