JAHA:急性冠状动脉综合征的糖尿病患者冠状动脉斑块特征

2018-07-14 xing.T MedSci原创

与非DM患者相比,DM患者在病变和非病变部位具有更多的脆弱特征,从而表现出更高水平的血管不稳定。

糖尿病(DM)是心血管事件的主要危险因素。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员的目的是通过光学相干断层扫描来评估发生急性冠状动脉综合征的糖尿病患者的冠状动脉斑块表型。

该研究共纳入了322名急性冠状动脉综合征患者,这些患者接受了光学相干断层扫描成像检查。研究人员比较了DM患者(n=95)和无DM患者(n=227)病变血管斑块的特征。在通过光学相干断层扫描成像检查了病变血管中足够长度非病变区域的250名患者组成的亚组中,研究人员还评估了非病变斑块的特征。

与没有DM的患者相比,DM患者出现富含脂质斑块(58.9% vs. 44.9%,P=0.030)和巨噬细胞积聚(60.0% vs. 44.9%,P=0.019)的患病率更高。斑块破裂(33.7% vs. 30.4%,P=0.896)和斑块侵蚀(21.1% vs. 22.0%,P=0.458)的患病率相似。在非病变血管中,与非DM患者相比,DM患者最大脂质弧更大(248.9°±83.9° vs. 179.9°±58.3°,P=0.006),纤维帽厚度更薄(103.3±56.2μm vs. 140.7±70.0μm,P=0.013),薄膜纤维粥样瘤的患病率更高(17.2% vs. 6.3%,P=0.031)。

与非DM患者相比,DM患者在病变和非病变部位具有更多的脆弱特征,从而表现出更高水平的血管不稳定。

原始出处:


Tomoyo Sugiyama.et al. Coronary Plaque Characteristics in Patients With Diabetes Mellitus Who Presented With Acute Coronary Syndromes.JAHA.2018. https://doi.org/10.1161/JAHA.118.009245

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    2018-07-16 zhaohui6731
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    2018-07-14 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-07-14 神功盖世

    0

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    2018-07-14 医者仁心5538

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