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JAMA:雌激素和孕激素与绝经后女性乳腺癌发病率和死亡率的研究

2011-05-06 MedSci原创 MedSci原创

雌激素乳腺癌
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出处：JAMA. 2010 Oct 20; 304(15):1684-92 作者：Chlebowski RT, Anderson GL, Gass M, Lane DS译者： F1000因子：10 评级：必读       背景：妇女健康倡议（Women's Health Initiative）是一项雌激素和孕激素的随机、安慰剂对照研究，平均干预时间为5.

出处：JAMA. 2010 Oct 20; 304(15):1684-92 作者：Chlebowski RT, Anderson GL, Gass M, Lane DS译者： F1000因子：10 评级：必读       背景：妇女健康倡议（Women's Health Initiative）是一项雌激素和孕激素的随机、安慰剂对照研究，平均干预时间为5.6年（标准差 SD，1.3）（范围3.7-8.6年），平均随访7.9年（SD 1.4），结果发现接受联合激素治疗的女性乳腺癌发病率增加。试验参与者的乳腺癌死亡率尚未报告。       目的：确定截止2009年8月14日共计平均随访11.0年（SD 2.7年）雌激素加孕激素治疗对乳腺癌累积发病率和死亡率的影响。设计、地点和受试者：美国40个临床中心共16,608名50至79岁既往未行子宫切除术的绝经后妇女，随机服用马结合雌激素 0.625mg/d和甲羟孕酮 2.5mg/d或服用安慰剂。在初始研究结束后（2005年3月31日），就继续随访乳腺癌的发病率

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    2012-03-20 12498636m49(暂无昵称)

    #癌发病#

    0

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    2012-01-12 zhaojie88

    #发病率#

    0

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    2011-11-17 chenhongpeng

    #癌发病率#

    0

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    2011-05-08 yeye5224612

    #绝经#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1799744, encodeId=82281e9974465, content=<a href='/topic/show?id=9e3fe127909' target=_blank style='color:#2F92EE;'>#癌发病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71279, encryptionId=9e3fe127909, topicName=癌发病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2c92500045, createdName=12498636m49(暂无昵称), createdTime=Tue Mar 20 03:27:00 CST 2012, time=2012-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823135, encodeId=60fe182313588, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 12 21:27:00 CST 2012, time=2012-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079207, encodeId=101820e92072d, content=<a href='/topic/show?id=659ce1280ee' target=_blank style='color:#2F92EE;'>#癌发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71280, encryptionId=659ce1280ee, topicName=癌发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Thu Nov 17 07:27:00 CST 2011, time=2011-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256958, encodeId=906e1256958c0, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385335, encodeId=b94f138533594, content=<a href='/topic/show?id=9aeb45318ed' target=_blank style='color:#2F92EE;'>#孕激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45318, encryptionId=9aeb45318ed, topicName=孕激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526593, encodeId=45a41526593ef, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631459, encodeId=93f3163145937, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=)]
    2011-05-08 dzx0922889

    #孕激素#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1799744, encodeId=82281e9974465, content=<a href='/topic/show?id=9e3fe127909' target=_blank style='color:#2F92EE;'>#癌发病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71279, encryptionId=9e3fe127909, topicName=癌发病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2c92500045, createdName=12498636m49(暂无昵称), createdTime=Tue Mar 20 03:27:00 CST 2012, time=2012-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823135, encodeId=60fe182313588, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 12 21:27:00 CST 2012, time=2012-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079207, encodeId=101820e92072d, content=<a href='/topic/show?id=659ce1280ee' target=_blank style='color:#2F92EE;'>#癌发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71280, encryptionId=659ce1280ee, topicName=癌发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Thu Nov 17 07:27:00 CST 2011, time=2011-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256958, encodeId=906e1256958c0, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385335, encodeId=b94f138533594, content=<a href='/topic/show?id=9aeb45318ed' target=_blank style='color:#2F92EE;'>#孕激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45318, encryptionId=9aeb45318ed, topicName=孕激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526593, encodeId=45a41526593ef, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631459, encodeId=93f3163145937, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=)]
    2011-05-08 chenhongpeng

    #绝经后女性#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1799744, encodeId=82281e9974465, content=<a href='/topic/show?id=9e3fe127909' target=_blank style='color:#2F92EE;'>#癌发病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71279, encryptionId=9e3fe127909, topicName=癌发病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2c92500045, createdName=12498636m49(暂无昵称), createdTime=Tue Mar 20 03:27:00 CST 2012, time=2012-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823135, encodeId=60fe182313588, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jan 12 21:27:00 CST 2012, time=2012-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079207, encodeId=101820e92072d, content=<a href='/topic/show?id=659ce1280ee' target=_blank style='color:#2F92EE;'>#癌发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71280, encryptionId=659ce1280ee, topicName=癌发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Thu Nov 17 07:27:00 CST 2011, time=2011-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256958, encodeId=906e1256958c0, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385335, encodeId=b94f138533594, content=<a href='/topic/show?id=9aeb45318ed' target=_blank style='color:#2F92EE;'>#孕激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45318, encryptionId=9aeb45318ed, topicName=孕激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526593, encodeId=45a41526593ef, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631459, encodeId=93f3163145937, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sun May 08 11:27:00 CST 2011, time=2011-05-08, status=1, ipAttribution=)]
    2011-05-08 zxxiang

    #绝经后#

    0