Nat Med:健康饮食很重要!肠道微生物与健康紧密相连

2021-01-23 MedSci原创 MedSci原创

肠道微生物与新陈代谢密切相关,紊乱的肠道菌群会导致多种常见代谢疾病的发生,比如肥胖,2型糖尿病和代谢性心脏病等等。诸多研究表明,肠道微生物与人体生理功能、健康和疾病关系密切。

肠道微生物与新陈代谢密切相关,紊乱的肠道菌群会导致多种常见代谢疾病的发生,比如肥胖,2糖尿病和代谢性心脏病等等。诸多研究表明,肠道微生物与人体生理功能、健康和疾病关系密切。近日,发表在Nat Med杂志的一项研究揭示了饮食、肠道微生物与健康之间的关系。

研究人员启动了饮食与微生物组在代谢中相互作用的研究(PREDICT 1),对1098名参与者的1203个肠道微生物组进行了深度宏基因组测序,并收集了参与者详细的长期饮食信息,以及数百次空腹和餐后心脏代谢的血液标记物水平变化。

结果发现,微生物与特定营养素,食物,食物类别和饮食指标之间存在诸多重要关联,尤其是健康和植物性食物。健康的饮食则是一种包含多种与慢性病风险较低相关的食物的饮食。摄入健康和植物性饮食可提高肠道有益菌。肠道中的一些微生物与代谢疾病的生物标志物水平存在关联。肠道内的普氏菌和囊胚菌时餐后葡萄糖代谢良好的指标。

个人因素、习惯性饮食、空腹和餐后标志物之间的关系

 

食物、食物组、营养素和饮食模式

整体微生物组数据可预测尚未出现症状的人确定心脏代谢疾病的风险,包括餐后血糖,血脂和炎症指标。值得一提的是,健康饮食习惯相关的肠道菌群与良好的心脏代谢和餐后标志物相关的肠道菌群重叠,通过这些肠道微生物组水平,可判断无临床症状个体的健康状况。与遗传因素相比,肠道微生物与患某些疾病的风险更高。

总体来说,健康饮食、微生物组和代谢之间有着密不可分关系。通过健康饮食可调节人的肠道中生活的生物群落,从而优化人的健康。

原始出处

Francesco AsnicarMicrobiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.Nature Medicine (2021)https://www.nature.com/articles/s41591-020-01183-8

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    2021-02-28 liye789132251
  3. [GetPortalCommentsPageByObjectIdResponse(id=1825243, encodeId=d2c21825243f0, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Mon Aug 16 06:04:54 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884924, encodeId=66d8188492456, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Feb 28 17:04:54 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=922957, encodeId=575a92295e43, content=xuexile, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=253f5447547, createdName=ms1000001573099445, createdTime=Fri Feb 05 08:46:26 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919687, encodeId=a67b91968e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Mon Jan 25 14:04:58 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610871, encodeId=f26616108e1b5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 25 07:04:54 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919277, encodeId=0bb09192e7fe, content=关系密切, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65c55455166, createdName=ms7000001087860977, createdTime=Sat Jan 23 19:53:33 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919263, encodeId=d397919263c8, content=健康饮食, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2102419085, createdName=12391246m97暂无昵称, createdTime=Sat Jan 23 19:06:06 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919259, encodeId=1482919259cd, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b9e5455145, createdName=ms6000001681093495, createdTime=Sat Jan 23 18:49:03 CST 2021, time=2021-01-23, status=1, ipAttribution=)]
    2021-02-05 ms1000001573099445

    xuexile

    0

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    2021-01-25 1486adbfm03暂无昵称

    学习了

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1825243, encodeId=d2c21825243f0, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Mon Aug 16 06:04:54 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884924, encodeId=66d8188492456, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Feb 28 17:04:54 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=922957, encodeId=575a92295e43, content=xuexile, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=253f5447547, createdName=ms1000001573099445, createdTime=Fri Feb 05 08:46:26 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919687, encodeId=a67b91968e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Mon Jan 25 14:04:58 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610871, encodeId=f26616108e1b5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 25 07:04:54 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919277, encodeId=0bb09192e7fe, content=关系密切, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65c55455166, createdName=ms7000001087860977, createdTime=Sat Jan 23 19:53:33 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919263, encodeId=d397919263c8, content=健康饮食, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2102419085, createdName=12391246m97暂无昵称, createdTime=Sat Jan 23 19:06:06 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919259, encodeId=1482919259cd, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b9e5455145, createdName=ms6000001681093495, createdTime=Sat Jan 23 18:49:03 CST 2021, time=2021-01-23, status=1, ipAttribution=)]
    2021-01-23 ms7000001087860977

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    2021-01-23 12391246m97暂无昵称

    健康饮食

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1825243, encodeId=d2c21825243f0, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Mon Aug 16 06:04:54 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884924, encodeId=66d8188492456, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Feb 28 17:04:54 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=922957, encodeId=575a92295e43, content=xuexile, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=253f5447547, createdName=ms1000001573099445, createdTime=Fri Feb 05 08:46:26 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919687, encodeId=a67b91968e8f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Mon Jan 25 14:04:58 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610871, encodeId=f26616108e1b5, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 25 07:04:54 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919277, encodeId=0bb09192e7fe, content=关系密切, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65c55455166, createdName=ms7000001087860977, createdTime=Sat Jan 23 19:53:33 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919263, encodeId=d397919263c8, content=健康饮食, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2102419085, createdName=12391246m97暂无昵称, createdTime=Sat Jan 23 19:06:06 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919259, encodeId=1482919259cd, content=真好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b9e5455145, createdName=ms6000001681093495, createdTime=Sat Jan 23 18:49:03 CST 2021, time=2021-01-23, status=1, ipAttribution=)]
    2021-01-23 ms6000001681093495

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