JAMDA:肌肉减少症和身体虚弱密切相关

2015-03-31 QQduhq 译 MedSci原创

目标:肌肉衰减症和身体虚弱都是引起老年人运动功能丧失和失去自主活动能力的老年综合征。这项研究旨在肌肉衰减症和身体虚弱引起生活在不同社区保健中心的老年人运动功能丧失和失去自主活动能力评定的共同条件。同时,为了更好地评估老年人身体虚弱情况,与广泛应用的Fried标准相比,我们使用FRAIL量表,并判断该量表的有效性。设计方式:我们从采用横断面研究的马斯特里赫特研究即MaSS中检索数据。环境:研究在荷兰

目标:
肌肉衰减症和身体虚弱都是引起老年人运动功能丧失和失去自主活动能力的老年综合征。这项研究旨在肌肉衰减症和身体虚弱引起生活在不同社区保健中心的老年人运动功能丧失和失去自主活动能力评定的共同条件。同时,为了更好地评估老年人身体虚弱情况,与广泛应用的Fried标准相比,我们使用FRAIL量表,并判断该量表的有效性。


设计方式:
我们从采用横断面研究的马斯特里赫特研究即MaSS中检索数据。

环境:
研究在荷兰南部著名古城马斯特里赫特市区几家不同的社区保健中心进行。

参与人员:
参与人员年龄都不少于65岁,都已签署书面知情同意书,他们都能听懂荷兰语,也不使用轮椅更不会卧床不起,且不采用任何干预处理。

研究方式:
肌肉减少症是欧洲研究组织针对老年人肌肉减少的命名方式。我们通过使用Fried标准和FRAIL量表评定老年人是否有身体虚弱症,并使用逻辑回归分析研究肌肉减少症和身体虚弱症(使用Fried标准评定)之间的关系,并使用相关分析来评估使用FRAIL量表与Fried标准的诊断身体虚弱的方式有何不同。

结果:
我们对227名平均年龄为74.9岁的老年人进行了研究分析,有23.3%的老人被确诊为肌肉减少症,轻度肌肉减少不列入范围内。使用Fried诊断标准确诊为身体虚弱症的老人占8.4%(至少符合三个条件即确诊),使用FRAIL量表确诊为身体虚弱症的老人占9.3%(至少符合三个条件即确诊)。研究表明,肌肉减少症与身体虚弱症明显相关(P=0.022)。身体虚弱的老人相比没有身体虚弱的人更容易得肌肉减少症,且随着年龄的增加,获得肌肉减少症风险的几率也逐渐增加。其次,且年老体弱的患者在其他身体活动功能测试中表现出握力差(占78.9%) 和步态缓慢(占89.5%),这些症状也是经常发生的。可以证明两个评估身体是否虚弱的量表是紧密关联(r=0.617,P<0.001)。

结论:
肌肉减少症和身体虚弱症紧密相关且诊断条件部分重复,尤其在一些身体功能方面的研究数据缺失的情况下更是如此。且试验表明,Fried量表和FRAIL量表存在一致的准确性。未来研究应着重探讨能够预防和治疗肌肉减少症和身体虚弱症的共同措施,并且可以避免伤残和其他身体问题的发生。

原始出处:

Mijnarends DM1, Schols JM2, Meijers JM3, Tan FE4, Verlaan S5, Luiking YC5, Morley JE6, Halfens RJ3.Instruments to assess sarcopenia and physical frailty in older people living in a community (care) setting: similarities and discrepancies.J Am Med Dir Assoc. 2015 Apr 1;16(4):301-8. doi: 10.1016/j.jamda.2014.11.011. Epub 2014 Dec 17.


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    2015-08-12 wetgdt
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    2015-04-02 zhty5337
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