Nat Genet:在猴子身上的研究将帮助人类找到对抗HIV的方法!

2017-11-02 sunshine2015 来宝网

在非洲和加勒比地区发现的猴子是疟疾免疫缺陷病毒(SIV)中最丰富的天然宿主,这是与艾滋病毒/艾滋病有着亲密关系的。

猴子身上发现的基因能表明对抗艾滋病方法】在非洲和加勒比地区发现的猴子是疟疾免疫缺陷病毒(SIV)中最丰富的天然宿主,这是与艾滋病毒/艾滋病有着亲密关系的。

与艾滋病病毒感染者不同,感染SIV的病毒很少患上猿猴艾滋病。

在一项新研究中,包括UWM人类学家Trudy Turner的研究小组发现,动物来自进化的容忍耐性有利于DNA中某些基因的发展。

在“自然遗传学”(Nature Genetics)10月30日发表的一篇论文中所述的针对病毒的可能的防御机制的发现可以为开发新的艾滋病毒/艾滋病治疗提供线索,并且可以告知未来艾滋病毒基因的进化。

长尾猴也被称为非洲绿猴,长期以来被用作各种人类疾病的生物医学模型。

特纳说,虽然从猴子到人类还有很长的路要走,但这项工作具有比较大的价值。例如,有些研究表明,它可以帮助科学家确定HIV和SIV是否具有共同的血统。

在研究人员的研究结果中,选择发生在动物调控病毒的基因中,而不是与它们作斗争。并且高度选择了控制免疫缺陷进展的基因。

该小组的抽样策略旨在调查从撒哈拉沙漠以南非洲到加勒比地区的不同群体的猴子的基因选择。

“样本的多样性很重要,所以我们可以确定进化选择来自大地理区域的广泛程度,”生物人类学教授特纳说。

动物对SIV的耐受性是2009年研究猴子的国际科学家联盟的主要原因。该联盟的整个基因组在2015年进行了测序,开辟了新的调查路线。

针对非洲实地工作的特纳说:“我们困扰并释放了2,000只动物,并研究了各种各样的生物学问题。 “但是最热的部分是在一些基因和SIV之间出现的关系。”

该组织对病毒基因组的适应性发现与最近的证据一致,即病毒在哺乳动物中发挥生命功能的蛋白质进化过程中发挥了重要作用。

原始出处:

Hannes Svardal, Anna J Jasinska, Cristian Apetrei, et al. Ancient hybridization and strong adaptation to viruses across African vervet monkey populations, Nature Genetics (2017). nature.com/articles/doi:10.1038/ng.3980.

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    2017-12-09 canlab
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    2018-04-23 cy0324
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    2018-07-18 liye789132251
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    2017-11-03 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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