转化医学

订阅

MedSci主页 / 所有栏目 / 转化医学

胞浆蛋白核转移让致命儿童脑瘤恶性程度更高

2016-10-05 佚名 生物谷

儿童脑瘤
关注

一些恶性的成神经细胞瘤在细胞核内存在一种特殊蛋白，而在一些良性的成神经细胞瘤的细胞核中并不存在，美国罗切斯特大学医学中心的研究人员通过研究得到了上述发现，这项发现将促进新靶向治疗方法的开发。EYA1是一个能够促进耳朵发育的蛋白，也出现在许多成神经细胞瘤的细胞质中，但是这种蛋白会在一些恶性的成神经细胞瘤细胞中向细胞核内迁移。这项研究最近发表在两个医学研究杂志上，有助于开发一些靶向药物用于阻止成神经细


一些恶性的成神经细胞瘤在细胞核内存在一种特殊蛋白，而在一些良性的成神经细胞瘤的细胞核中并不存在，美国罗切斯特大学医学中心的研究人员通过研究得到了上述发现，这项发现将促进新靶向治疗方法的开发。

EYA1是一个能够促进耳朵发育的蛋白，也出现在许多成神经细胞瘤的细胞质中，但是这种蛋白会在一些恶性的成神经细胞瘤细胞中向细胞核内迁移。这项研究最近发表在两个医学研究杂志上，有助于开发一些靶向药物用于阻止成神经细胞瘤发展到更加恶性的阶段。研究人员已经在实验室内开始对一些治疗方法进行检测。

"成神经细胞瘤是最常见也是最致命的一种儿童癌症，这项发现帮助我们发现了一些能够阻止EYA1结构改变的药物，有助于减小患儿的危险程度。"Nina Schor教授这样说道。

EYA1蛋白进入癌细胞的细胞核是由于PRMT1这个酶的出现。这种酶也会增加另外一种蛋白的表达，N-MYC，该蛋白一直都被认为能够增加成神经细胞瘤的恶性程度。

因此通过限制PRMT1的活性，研究人员认为他们能够同时降低上述两种蛋白造成的损伤。"PRMT1抑制剂可能会在成神经细胞瘤的恶性程度变得更高之前达到一种一箭双雕的效果。"Schor这样说道。

相关研究结果发表在国际学术期刊Journal of Cancer Research ＆ Therapy 和Oncotarget上。

原始出处

Allison Eberhardt, Jeanne N. Hansen, Jan Koster, Louis T. Lotta Jr, Simeng Wang, Emmett Livingstone, Kun Qian, Linda J. Valentijn, Yujun George Zheng, Nina F. Schor, Xingguo Li.Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=146162, encodeId=6959146162f5, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:44 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146159, encodeId=a456146159ee, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275677, encodeId=08cc12e56771b, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Fri Oct 07 06:18:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141080, encodeId=c8d61410809e, content=謝謝分享，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:39 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141079, encodeId=9a7e1410e95b, content=學習啦，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:33 CST 2016, time=2016-10-06, status=1, ipAttribution=)]
    2016-10-11 知难而进

    继续关注！

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=146162, encodeId=6959146162f5, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:44 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146159, encodeId=a456146159ee, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275677, encodeId=08cc12e56771b, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Fri Oct 07 06:18:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141080, encodeId=c8d61410809e, content=謝謝分享，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:39 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141079, encodeId=9a7e1410e95b, content=學習啦，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:33 CST 2016, time=2016-10-06, status=1, ipAttribution=)]
    2016-10-11 知难而进

    谢谢分享！

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=146162, encodeId=6959146162f5, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:44 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146159, encodeId=a456146159ee, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275677, encodeId=08cc12e56771b, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Fri Oct 07 06:18:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141080, encodeId=c8d61410809e, content=謝謝分享，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:39 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141079, encodeId=9a7e1410e95b, content=學習啦，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:33 CST 2016, time=2016-10-06, status=1, ipAttribution=)]
    2016-10-07 jxrzshh

    #脑瘤#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=146162, encodeId=6959146162f5, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:44 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146159, encodeId=a456146159ee, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275677, encodeId=08cc12e56771b, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Fri Oct 07 06:18:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141080, encodeId=c8d61410809e, content=謝謝分享，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:39 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141079, encodeId=9a7e1410e95b, content=學習啦，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:33 CST 2016, time=2016-10-06, status=1, ipAttribution=)]
    2016-10-06 医路开来

    謝謝分享，，

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=146162, encodeId=6959146162f5, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:44 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146159, encodeId=a456146159ee, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 22:46:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275677, encodeId=08cc12e56771b, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Fri Oct 07 06:18:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141080, encodeId=c8d61410809e, content=謝謝分享，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:39 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141079, encodeId=9a7e1410e95b, content=學習啦，，, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 14:22:33 CST 2016, time=2016-10-06, status=1, ipAttribution=)]
    2016-10-06 医路开来

    學習啦，，

    0

相关资讯

环保部：26.8%被调查儿童暴露在室内空气污染中

为了解我国人群环境暴露行为特点，提高环境健康风险评价的科学性，环保部于“十二五”期间首次组织全国性、大规模人群环境暴露行为模式研究。继2014年发布成人（18岁及以上）研究成果后，昨天，环保部再次向社会发布了儿童（0～17岁）环境暴露行为模式研究成果。调查结果显示，在本次调查的儿童中，26.8%暴露于固体燃料做饭或取暖带来的室内空气污染，12.7%饮用未经基础卫生设施集中处理的地下水、地表水或窖水

管住抗生素，先管住医生

导语：今年起，全国各地纷纷叫停门诊输液，出台“限抗令”。9月16日本报推出《打点滴的是是非非》一文后，收到许多专家读者的热情反馈。广东省医学会副会长、南方医科大学儿科教授曾其毅表示，抗生素滥用在临床上依然存在，而且很多医生并没有真正了解抗生素的危害，在这方面，他有很多话要说。受访专家：广东省医学会副会长、南方医科大学儿科教授    曾其毅问题都在一个“滥”字 吊瓶与抗

聚焦2016CTS 首次多学科《雾化吸入疗法在呼吸疾病中的应用专家共识》 《支气管哮喘防治指南（2016年版）》 发布仪式暨新闻发布会顺利召开

2016年9月22-25日， 2016中华医学会呼吸病学年会-第十七次全国呼吸病学学术会议在陕西省西安市盛大召开。在此期间举行了《雾化吸入疗法在呼吸疾病中的应用专家共识》（以下简称《雾化共识》）和《支气管哮喘防治指南（2016版）》（以下简称《哮喘指南》）新闻发布会。出席此次发布会的有中国工程院钟南山院士、王辰院士以及林江涛教授、康健教授、沈华浩教授、陈荣昌教授、文富强教授、周新教授、瞿介明教

儿童每星期摄糖量应该限于25克！

美国心脏病学会公布儿童摄糖新标准 学会推出的新指南建议：年龄在2到18岁之间的儿童青少年每星期摄糖量应该限于6茶匙（25克），包括用来加工制备食物或饮料，以及添加到食物中或用来单独食用的任何糖类。此外每周喝含糖饮料不能超过8盎司。《循环学》杂志刊登的这项新指南也建议不要给2岁以下的儿童添加任何糖分。 AAP News (8/23)研究表明脑震荡后继续运动会延长其恢复时间 脑震荡后立即退出运动的学生

Heart：儿童心力衰竭新生物标志物的诊断性能及参考值

由此可见，中段ProANF能精确检测儿童和青少年中的心衰患者，其诊断性能与NT-proBNP媲美。

大麻提取物(Epidiolex)治疗难治性儿童癫痫再显奇效

英国GW制药公司近日公布了大麻提取物Epidiolex（cannabidiol，大麻二醇，CBD）治疗Lennox-Gastaut综合征（LGS）的第二个随机、双盲、安慰剂对照III期临床研究的积极数据。LGS是一种罕见的、严重的、难治性儿童期发作癫痫。该项研究中的患者之前已尝试过平均7种抗癫痫药物，目前正在接受平均3种药物治疗。 研究中，将安慰剂或Epidiolex添加至患者当前的治疗方案