J Hypertens:终末期肾病患者血压与左室质量变化相关吗?

2017-05-30 xing.T MedSci原创

由此可见,在接受血液透析的患者中,初始MAP的变化与1年后LVMI的变化之间相关性最好。但仍需进一步的研究以确定它是否可以作为一个潜在的有用治疗目标以防止不良心室重塑,从而改善心血管预后。

接受血液透析治疗的患者血压测量的最佳时机尚未确定。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员试图确定哪次血压测量变化与终末期肾脏疾病患者1年后左心室重量指数(LVMI)变化之间的相关性最好。

研究人员将57例患者纳入前瞻性队列研究,比较了中心夜间血液透析和持续常规血液透析转换对心血管的影响。在研究之初和随访1年后,研究人员对受试者不同的时间点(透析前、开始透析后、在透析后的最低点以及透析后)测量并记录血压。并在研究之初和随访1年后,经单盲的读片者独立评估经心脏磁共振成像测量的LVMI。

总体而言,在研究之初,参与者的平均LVMI为69.9克/平方米(标准差为15.9),1年后为69.6克/平方米(标准差为16)。研究人员发现初始平均动脉压(MAP)的变化与LVMI的变化相关性最为密切(皮尔森相关系数r=0.71,P<0.001)。在透析组和多变量分析中这种相关性较为相似。在配对比较中,初始MAP与LVMI变化之间的相关性最好,比透析最低点和透析后的血压指标均要好(所有P<0.05)。然而,研究人员发现其与透析前SBP之间的相关性并不强(P=0.33)。

由此可见,在接受血液透析的患者中,初始MAP的变化与1年后LVMI的变化之间相关性最好。但仍需进一步的研究以确定它是否可以作为一个潜在的有用治疗目标以防止不良心室重塑,从而改善心血管预后。

原始出处:

Sarak, Bradley;et al. Relationship between changes in blood pressure and left ventricular mass over 1 year in end-stage renal disease.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Relationship_between_changes_in_blood_pressure_and.97758.aspx

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    2017-05-30 cqykthl

    血液透析患者的血压不好控制

    0

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    2017-05-30 tanxingdoctor

    学习啦谢谢分享

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