Oncol Lett：LncRNA PEG10过表达可促进鳞状细胞癌的进展

2017-09-29 MedSci MedSci原创

本研究旨在调查长链非编码RNA PEG10（lncRNA PEG10）过表达对下咽鳞状细胞癌（HSCC）细胞的增殖、侵袭和转移的影响。采用定量逆转录聚合酶链反应定量检测HSCC肿瘤组织样本、癌旁组织样本和HSCC FaDu细胞系中的lncRNA PEG10的表达水平。分别使用细胞增殖试验、Transwell侵袭试验和伤口愈合试验评价lncRNA PEG10对体外FaDu细胞的影响。结果显示，在56

本研究旨在调查长链非编码RNA PEG10（lncRNA PEG10）过表达对下咽鳞状细胞癌（HSCC）细胞的增殖、侵袭和转移的影响。

采用定量逆转录聚合酶链反应定量检测HSCC肿瘤组织样本、癌旁组织样本和HSCC FaDu细胞系中的lncRNA PEG10的表达水平。分别使用细胞增殖试验、Transwell侵袭试验和伤口愈合试验评价lncRNA PEG10对体外FaDu细胞的影响。

结果显示，在56例符合纳入标准的患者中，与癌旁组织相比，HSCC肿瘤组织中lncRNA PEG10的表达水平较高，且lncRNA PEG10的表达增加与原发肿瘤大小、淋巴结状态和肿瘤淋巴结转移阶段之间存在明显地相关性。体外实验研究中发现，lncRNA PEG10的表达升高与FaDu细胞的增殖、侵袭和转移增加明显相关。

总之，该研究表明，LncRNA PEG10在HSCC中表达升高，且其过表达可促进HSCC细胞的增殖、侵袭和转移。仍需进一步的研究以深入探究潜在的机制。

原始出处：

Miaoqing Zhao, Dianshui Sun, et al., Overexpression of long noncoding RNA PEG10 promotes proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma. Oncol Lett. 2017 Sep; 14(3): 2919–2925. Published online 2017 Jun 30. doi: 10.3892/ol.2017.6498.

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2018-01-11 lq1767

#过表达#

26 0
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2018-09-07 feather89

#PE#

16 0
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2017-12-07 qingting

#细胞癌#

22 0
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2018-07-19 minlingfeng

#Oncol#

25 0
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2018-06-16 yanjie6253_56072842

#CRN#

23 0
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2017-10-03 yunger

谢谢哈.有提醒价值的

37 0
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2017-10-01 xzw113

#lncRNA#

21 0
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2017-10-01 wleon8899

#PEG#

21 0
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2017-09-30 lietome15

好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

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Oncol Lett：LncRNA PEG10过表达可促进鳞状细胞癌的进展

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