Circulation:细数主动脉瓣置换术相关影响因素

2015-09-30 张旭栋 MedSci原创

背景:依据术前左心室(LV)功能,明确主动脉瓣置换术(AVR)后,死亡率与充血性心力衰竭之间的关联;并描述发病率,手术时机,左心室恢复与左心室逆转之间的关联。方法和结果:研究纳入了3112例AVR术的患者,对后续临床超声心动图进行了为期中位6年的随访。手术时,他们的平均年龄为67.8±13.4年,其中三分之一为女性,29%左室功能不全(射血分数<50%)。严重主动脉狭窄和左心室功能不全的患者

背景:依据术前左心室(LV)功能,明确主动脉瓣置换术(AVR)后,死亡率与充血性心力衰竭之间的关联;并描述发病率,手术时机,左心室恢复与左心室逆转之间的关联。

方法和结果:研究纳入了3112例AVR术的患者,对后续临床超声心动图进行了为期中位6年的随访。手术时,他们的平均年龄为67.8±13.4年,其中三分之一为女性,29%左室功能不全(射血分数<50%)。严重主动脉狭窄和左心室功能不全的患者,经主动脉瓣平均压力梯度<40毫米汞柱,体外循环转流时间和人工心脏瓣膜-患者不匹配(有效瓣口面积指数≤0.85厘米(2​​)/ m(2))是AVR术后死亡或充血性心力衰竭的独立的相关因素。明确严重主动脉反流和左心室功能不全患者的年龄和术前左心室质量。 主动脉瓣狭窄患者,左心室功能恢复与生存和心衰缓解相关。主动脉瓣狭窄患者左心室逆转时间需要24个月,主动脉反流患者左心室逆转需要5年。独立相关因素包括主动脉瓣狭窄患者左心室收缩末期内径缩小和主动脉瓣反流患者较低的纽约心脏学会心功能分级。

结局:左心室不完全恢复,人工心脏瓣膜-患者不匹配,低的主动脉瓣跨瓣压差和高的左心室质量都会增加左室功能不全患者AVR术后死亡率或心脏衰竭率。左心室收缩末期内径和左心室逆转程度呈负相关。这些发现有助于外科医生和心脏病专家确定AVR术前术后适应证,时机,关于疾病结局的预测以及后续随访。

原文出处:

Une D, Mesana L, Chan V, Maklin M, Chan R, Masters RG, Mesana TG, Ruel M (2015) Clinical Impact of Changes in Left Ventricular Function After Aortic Valve Replacement: Analysis From 3112 Patients. Circulation 132 (8):741-747. doi:10.1161/circulationaha.115.015371

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