JAHA:肝脏脂肪与房颤发病率和患病率之间有啥关系?

2017-05-04 xing.T MedSci原创

在社区为基础的纵向队列研究中,研究人员发现通过计算机断层扫描得到的肝脏脂肪与随访12年后房颤的患病率和发病率之间没有显著的相关性。

肥胖是非酒精性脂肪性肝病和房颤的重要危险因素,然而,有关非酒精性脂肪性肝病与房颤之间的相关性研究人员知之甚少,近日,心血管领域权威杂志JAHA上发表了一篇研究文章,研究人员试图评估脂肪肝与社区人群房颤患病率和发病率之间的关系。

研究人员评估了Framingham心脏研究的参与者,这些参与者接受了计算机断层扫描检查,并对其肝脂肪变性进行了评估,这些参与者在2002年和2005年期间没有重度饮酒。研究人员采用logistic回归模型评估了肝脏脂肪与房颤发病率之间的横断面相关性。同时,采用Cox比例风险模型评估了随访12年后肝脂肪和房颤发生之间的相关性。

2122名参与者(53%的女性,平均年龄为59±9.6岁),20%的患者存在肝脂肪变性。在肝脂肪变性的患者(n=62)中房颤患病率为4%,相比那些没有肝脂肪变性的患者为3%。在年龄和性别调整后或多变量调整后的模型中,肝脂肪变性与房颤之间无显著相关性。在有和无肝脂肪变性的参与者中房颤发生率分别为8.7例和7.8例每1000人每年。在年龄和性别调整后或多变量调整后的模型中,研究人员没有发现肝脂肪变性连续或二分类指标与房颤发生之间存在显著相关性。

在这项社区为基础的纵向队列研究中,研究人员发现通过计算机断层扫描得到的肝脏脂肪与随访12年后房颤的患病率和发病率之间没有显著的相关性。

原始出处:

Michelle T. Long, et al. Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study.JAHA. 2017. https://doi.org/10.1161/JAHA.116.005227

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    2018-03-23 lifestar
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    2017-05-09 zhpyhd

    理论如此,感觉应该有关系

    0

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    2017-05-08 jacob9231

    学习了,谢谢分享

    0

  4. 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    2017-05-07 童小孩

    学习

    0

  5. 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    2017-05-06 zhaohui6731
  6. 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  8. 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    2017-05-06 童小孩

    学习

    0

  9. 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    2017-05-06 o9887

    学习了

    0

  10. 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    2017-05-05 1ddf0692m34(暂无匿称)

    涨知识,学习了

    0